Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | CNR2 | P34972 | 6/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | USP14 | P54578 | 1/20 | 0.48 |
| ▸ | USP7 | Q93009 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 5/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923380 | 0.88 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1HPGDRAB9AALDH1A1 | |
| SCHEMBL6923383 | 0.86 | SMN1; SMN2 (0.63) | SMN1; SMN2NPC1HPGDRAB9AALDH1A1 | |
| SCHEMBL17949724 | 0.78 | RAB9A (0.82) | SMN1; SMN2NPC1HPGDRAB9AALDH1A1 | |
| SCHEMBL17949737 | 0.77 | RAB9A (0.65) | SMN1; SMN2NPC1HPGDRAB9AALDH1A1 | |
| SCHEMBL6923152 | 0.76 | NOTUM (0.55) | SMN1; SMN2NPC1HPGDRAB9AALDH1A1 | |
| SCHEMBL20662804 | 0.74 | TAS1R3 (0.64) | SMN1; SMN2NPC1HPGDRAB9AALDH1A1 | |
| SCHEMBL23559409 | 0.73 | USP14 (0.65) | SMN1; SMN2NPC1HPGDRAB9AALDH1A1 | |
| SCHEMBL17949745 | 0.73 | USP14 (0.65) | SMN1; SMN2NPC1HPGDRAB9AALDH1A1 | |
| SCHEMBL23524513 | 0.72 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1HPGDRAB9AALDH1A1 | |
| SCHEMBL6921620 | 0.72 | USP14 (0.63) | SMN1; SMN2ALDH1A1CNR2NPSR1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9849135-B2 | USP14 inhibitors for treating or preventing viral infections | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-12-26 | — | — | US | disclosed |