Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.48 |
| ▸ | MEN1 | O00255 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.48 |
| ▸ | NOX1 | Q9Y5S8 | 7/20 | 0.48 |
| ▸ | GAA | P10253 | 6/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | SNCA | P37840 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydromethylthionine SCHEMBL29356148 | 0.91 | SNCA (0.50) | MAPTMEN1KMT2ANOX1GAA | |
| Hydromethylthionine SCHEMBL12592446 | 0.91 | SNCA (0.50) | MAPTMEN1KMT2ANOX1GAA | |
| Hydromethylthionine SCHEMBL109756 | 0.91 | SNCA (0.50) | MAPTMEN1KMT2ANOX1GAA | |
| Hydromethylthionine SCHEMBL12470963 | 0.89 | SNCA (0.48) | MAPTMEN1KMT2ANOX1GAA | |
| Hydromethylthionine SCHEMBL31159649 | 0.89 | SNCA (0.48) | MAPTMEN1KMT2ANOX1GAA | |
| Hydromethylthionine SCHEMBL25199191 | 0.89 | SNCA (0.48) | MAPTMEN1KMT2ANOX1GAA | |
| Hydromethylthionine SCHEMBL31159644 | 0.89 | SNCA (0.48) | MAPTMEN1KMT2ANOX1GAA | |
| Hydromethylthionine SCHEMBL23683393 | 0.89 | SNCA (0.48) | MAPTMEN1KMT2ANOX1GAA | |
| Hydromethylthionine SCHEMBL25194477 | 0.89 | SNCA (0.48) | MAPTMEN1KMT2ANOX1GAA | |
| Hydromethylthionine SCHEMBL1577040 | 0.89 | SNCA (0.48) | MAPTMEN1KMT2ANOX1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11707452-B2 | Modulators of alpha-synuclein proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-11707452-B2 | Modulators of alpha-synuclein proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-10864216-B2 | Phenothiazine diaminium salts and their use | WISTA LABORATORIES, LTD. (SG) | 2020-12-15 | — | — | US | disclosed |
| WO-2020041331-A1 | PROTEOLYSIS TARGETING CHIMERIC (PROTAC) COMPOUND WITH E3 UBIQUITIN LIGASE BINDING ACTIVITY AND TARGETING ALPHA-SYNUCLEIN PROTEIN FOR TREATING NEURODEGENERATIVE DISEASES | ARVINAS OPERATIONS, INC. (US) | 2020-02-27 | — | — | WO | disclosed |
| US-20190046537-A1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | WISTA LABORATORIES LTD. (SG) | 2019-02-14 | — | — | US | disclosed |
| EP-2673266-B1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | WISTA LAB LTD (SG) | 2016-07-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11707452-B2 | Modulators of alpha-synuclein proteolysis and associated methods of use | UCHL1, ADRM1, CRBN | MAPT 741/4885MEN1 3483/4885KMT2A 2032/4885 |
| US-10864216-B2 | Phenothiazine diaminium salts and their use | QDPR, SLC35A1, SLC6A7 | MAPT 184/4885MEN1 655/4885KMT2A 2738/4885 |
| US-20190046537-A1 | PHENOTHIAZINE DIAMINIUM SALTS AND THEIR USE | QDPR, SLC35A1, SLC6A7 | MAPT 184/4885MEN1 655/4885KMT2A 2738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.