SCHEMBL17952984

SCHEMBL17952984

CC1=Cc2c(-c3cccc4ccccc34)cccc2C1CC1C(C)=Cc2c1cccc2N1CCCc2ccccc21

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.34
CHRM4 P08173 1/20 0.34
CHRM1 P11229 1/20 0.34
CHRM3 P20309 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
JAK2 O60674 1/20 0.33
JAK3 P52333 1/20 0.33
PTK2 Q05397 1/20 0.33
ROCK1 Q13464 1/20 0.33
TUBB4A P04350 3/20 0.32
TUBB P07437 3/20 0.32
TUBA3C P0DPH7 3/20 0.32
TUBA1B P68363 3/20 0.32
TUBA4A P68366 3/20 0.32
TUBB4B P68371 3/20 0.32
TUBB3 Q13509 3/20 0.32
TUBB2A Q13885 3/20 0.32
TUBB8 Q3ZCM7 3/20 0.32
TUBA3E Q6PEY2 3/20 0.32
TUBA1A Q71U36 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17952990 0.94 SMN1; SMN2 (0.34) ROCK1HTR7HTR1AALDH1A1MAPT
SCHEMBL17169025 0.89 MEN1 (0.38) L3MBTL1JAK2JAK3PTK2ROCK1
SCHEMBL17952983 0.87 L3MBTL1 (0.35) L3MBTL1JAK2JAK3PTK2ROCK1
SCHEMBL17952987 0.86 JAK2 (0.38) L3MBTL1JAK2JAK3PTK2ROCK1
SCHEMBL19336701 0.86 L3MBTL1 (0.33) CHRM2CHRM4CHRM1CHRM3L3MBTL1
SCHEMBL17074035 0.85 L3MBTL1 (0.35) CHRM2CHRM4CHRM1CHRM3L3MBTL1
Hydrochloric Acid SCHEMBL19453221 0.84 ROCK1 (0.34) L3MBTL1JAK2JAK3PTK2ROCK1
SCHEMBL17074019 0.83 L3MBTL1 (0.31) L3MBTL1JAK2JAK3PTK2ROCK1
SCHEMBL17082247 0.83 MEN1 (0.33) CHRM2CHRM4CHRM1CHRM3L3MBTL1
SCHEMBL17169024 0.82 SMN1; SMN2 (0.39) ROCK1ALDH1A1MAPTKDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9790240-B2 Ligand compound, a preparation method thereof, a transition metal compound, and a preparation method thereof LG CHEM, LTD. (KR) 2017-10-17 US disclosed
US-20160215004-A1 A NOVEL LIGAND COMPOUND, A PREPARATION METHOD THEREOF, A TRANSITION METAL COMPOUND, AND A PREPARATION METHOD THEREOF LG CHEM, LTD. (KR) 2016-07-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160215004-A1 A NOVEL LIGAND COMPOUND, A PREPARATION METHOD THEREOF, A TRANSITION METAL COMPOUND, AND A PREPARATION METHOD THEREOF CD40LG, OSTC, TNFSF10 CHRM2 2987/4885CHRM4 1369/4885CHRM1 2666/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.