Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | STAT3 | P40763 | 2/20 | 0.49 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17938670 | 0.91 | GPR183 (0.52) | STAT3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL17109276 | 0.85 | STAT3 (0.53) | ALDH1A1KDM4EPOLBSTAT3PRKAB2 | |
| SCHEMBL17938673 | 0.83 | SMN1; SMN2 (0.52) | ALDH1A1KDM4ESTAT3PRKAB2PRKAG1 | |
| SCHEMBL20765490 | 0.82 | MAPK14 (0.54) | ALDH1A1KDM4EPOLBMAPK14NPC1 | |
| SCHEMBL1063883 | 0.79 | L3MBTL1 (0.56) | ALDH1A1KDM4EPOLBPRKAA2MAPK14 | |
| SCHEMBL19970806 | 0.77 | SIGMAR1 (0.61) | STAT3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL17109174 | 0.77 | SIGMAR1 (0.53) | ALDH1A1STAT3PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL17109275 | 0.77 | PRKAA2 (0.50) | STAT3PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL6277953 | 0.76 | LSS (0.57) | ALDH1A1KDM4EPOLBSTAT3MAPK14 | |
| SCHEMBL17115840 | 0.76 | PRKAA2 (0.59) | ALDH1A1STAT3PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9776979-B2 | EBI2 modulators | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2017-10-03 | — | — | US | disclosed |
| US-20160214951-A1 | EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2016-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214951-A1 | EBI2 MODULATORS | BIRC2, HAVCR2, MAVS | ALDH1A1 4277/4885KDM4E 1496/4885POLB 3835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.