Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2000194 | 0.94 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2MAPK1NPC1RAB9A | |
| SCHEMBL28286266 | 0.86 | RAB9A (0.51) | ALDH1A1SMN1; SMN2MAPK1NPC1RAB9A | |
| SCHEMBL30494127 | 0.81 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2MAPK1NPC1RAB9A | |
| SCHEMBL724711 | 0.81 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2MAPK1NPC1RAB9A | |
| SCHEMBL2001591 | 0.80 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2MAPK1NPC1RAB9A | |
| SCHEMBL15447229 | 0.79 | HTT (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL17974313 | 0.79 | NPC1 (0.46) | ALDH1A1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL21865083 | 0.79 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2MAPK1NPC1RAB9A | |
| SCHEMBL12571875 | 0.78 | TSHR (0.52) | ALDH1A1SMN1; SMN2MAPK1RAB9AGAA | |
| SCHEMBL4538765 | 0.78 | MAOB (0.61) | ALDH1A1SMN1; SMN2MAPK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10968233-B2 | Monothiol mucolytic agents | PARION SCIENCES, INC. (US) | 2021-04-06 | — | — | US | disclosed |
| CN-112321472-A | Novel monothiol mucolytic agents | 帕里昂科学公司 | 2021-02-05 | — | — | CN | disclosed |
| CN-107614480-B | Novel monothiol mucolytic agents | 帕里昂科学公司 | 2020-09-15 | — | — | CN | disclosed |
| US-20190031679-A1 | NOVEL MONOTHIOL MUCOLYTIC AGENTS | PARION SCIENCES, INC. | 2019-01-31 | — | — | US | disclosed |
| US-10106551-B2 | Monothiol mucolytic agents | PARION SCIENCES, INC. (US) | 2018-10-23 | — | — | US | disclosed |
| CN-107614480-A | Novel monothiol mucolytic agents | 帕里昂科学公司 | 2018-01-19 | — | — | CN | disclosed |
| EP-3250548-A1 | NOVEL MONOTHIOL MUCOLYTIC AGENTS | Parion Sciences, Inc. (US) | 2017-12-06 | — | — | EP | disclosed |
| US-20160222023-A1 | NOVEL MONOTHIOL MUCOLYTIC AGENTS | PARION SCIENCES, INC. (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160222023-A1 | NOVEL MONOTHIOL MUCOLYTIC AGENTS | PARION SCIENCES, INC. (US) | 2016-08-04 | — | — | US | disclosed |
| US-20160222023-A1 | NOVEL MONOTHIOL MUCOLYTIC AGENTS | PARION SCIENCES, INC. (US) | 2016-08-04 | — | — | US | disclosed |
| WO-2016123335-A1 | NOVEL MONOTHIOL MUCOLYTIC AGENTS | PARION SCIENCES, INC. (US) | 2016-08-04 | — | — | WO | disclosed |
| WO-2016123335-A1 | NOVEL MONOTHIOL MUCOLYTIC AGENTS | PARION SCIENCES, INC. (US) | 2016-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10106551-B2 | Monothiol mucolytic agents | MUC1, HRH2, MAN2A1 | ALDH1A1 301/4885SMN1; SMN2 3077/4885MAPK1 3591/4885 |
| US-10968233-B2 | Monothiol mucolytic agents | MUC1, HRH2, MAN2A1 | ALDH1A1 301/4885SMN1; SMN2 3077/4885MAPK1 3591/4885 |
| US-20190031679-A1 | NOVEL MONOTHIOL MUCOLYTIC AGENTS | MUC1, MAN2A1, HRH2 | ALDH1A1 266/4885SMN1; SMN2 3630/4885MAPK1 3080/4885 |
| US-20160222023-A1 | NOVEL MONOTHIOL MUCOLYTIC AGENTS | MUC1, MAN2A1, HRH2 | ALDH1A1 266/4885SMN1; SMN2 3630/4885MAPK1 3080/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.