Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 2/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144329 | 0.72 | PDGFRA (0.44) | ALDH1A1KDM4ELMNAHTTPDE10A | |
| SCHEMBL31559879 | 0.69 | DUT (0.33) | — | |
| SCHEMBL31559837 | 0.69 | KDM4E (0.37) | ALDH1A1KDM4ELMNACASP3 | |
| SCHEMBL16596064 | 0.68 | RET (0.36) | LMNAHTTPDE10ACASP3MPO | |
| SCHEMBL16369689 | 0.68 | LMNA (0.42) | ALDH1A1KDM4ELMNAHTTPDE10A | |
| SCHEMBL16369724 | 0.67 | MCHR1 (0.41) | ALDH1A1KDM4ELMNAHTTPDE10A | |
| SCHEMBL2593177 | 0.66 | APAF1 (0.45) | ALDH1A1KDM4ELMNAHPGDHTT | |
| SCHEMBL23320542 | 0.66 | CA9 (0.49) | ALDH1A1KDM4ELMNAKMT2AMPO | |
| SCHEMBL4933697 | 0.65 | ALDH1A1 (0.47) | ALDH1A1KDM4ELMNAHPGDMTOR | |
| SCHEMBL15687441 | 0.65 | HTT (0.38) | ALDH1A1KDM4ELMNAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016123629-A1 | INDAZOLE AND AZAINDAZOLE SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY (US) | 2016-08-04 | — | — | WO | disclosed |