⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL332660 | 0.76 | CA12 (0.31) | — | |
| SCHEMBL336386 | 0.76 | — | — | |
| SCHEMBL3880729 | 0.70 | LMNA (0.38) | — | |
| SCHEMBL12616632 | 0.67 | CA2 (0.35) | — | |
| SCHEMBL4000892 | 0.67 | CA12 (0.38) | — | |
| SCHEMBL335048 | 0.63 | CA2 (0.38) | — | |
| SCHEMBL1801319 | 0.63 | CYP2A6 (0.33) | — | |
| SCHEMBL1796470 | 0.62 | CA1 (0.33) | — | |
| SCHEMBL1523787 | 0.61 | CA2 (0.46) | — | |
| SCHEMBL4440557 | 0.57 | ENPP2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102316871-B | [1,2,4]thiadiazine 1,1-dioxide compounds | ANADYS PHARMACEUTICALS INC | 2014-06-04 | — | — | CN | disclosed |
| CN-103827100-A | [1,2,4]thiadiazine 1,1-dioxide compounds for lowering serum uric acid | ANADYS PHARMACEUTICALS INC | 2014-05-28 | — | — | CN | disclosed |
| CN-102316871-A | [1,2,4]thiadiazine 1,1-dioxide compounds | ANADYS PHARMACEUTICALS INC | 2012-01-11 | — | — | CN | disclosed |
| US-7951800-B2 | Anti-infective agents | ABBOTT LABORATORIES, INC. (US) | 2011-05-31 | — | — | US | disclosed |
| US-20100120753-A1 | Anti-Infective Agents | ABBOTT LABORATORIES (US) | 2010-05-13 | — | — | US | disclosed |
| US-7662958-B2 | e.g. N-[3-{1-[(cyclobutyl)amino]-4-hydroxy-2-oxo-1,2-dihydro-quinolin -3-yl}-1,1-dioxo-1,4-dihydro-1 lambda 6-thieno[2,3-e][1,2,4]thiadiazin-7-yl)methyl]methane-sulfonamide; viricides for infections caused by an RNA-containing virus; hepatitis C virus (HCV) polymerase inhibitor; liver cirrhosis | ABBVIE INC. | 2010-02-16 | — | — | US | disclosed |
| US-20080214528-A1 | ANTI-INFECTIVE AGENTS | ABBVIE INC. | 2008-09-04 | — | — | US | disclosed |
| WO-2008011337-A1 | HCV INHIBITORS | ABBOTT LABORATORIES (US) | 2008-01-24 | — | — | WO | disclosed |