Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | TNF | P01375 | 2/20 | 0.43 |
| ▸ | FADS1 | O60427 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.38 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17963935 | 0.89 | SCN9A (0.46) | SCN9AMAP4K4HTR3EHTR3BHTR3A | |
| SCHEMBL17974329 | 0.81 | TNF (0.40) | SCN9AMAP4K4HTR3EHTR3BHTR3A | |
| SCHEMBL17963889 | 0.80 | SCN9A (0.42) | SCN9AHTR3EHTR3BHTR3AROCK1 | |
| SCHEMBL31240734 | 0.80 | HTR3E (0.50) | SCN9AHTR3EHTR3BHTR3AROCK1 | |
| SCHEMBL17974207 | 0.78 | SCN9A (0.40) | SCN9AHTR3EHTR3BHTR3AROCK1 | |
| SCHEMBL17974228 | 0.78 | JAK2 (0.43) | SCN9AHTR3EHTR3BHTR3AROCK1 | |
| SCHEMBL17974227 | 0.76 | ASIC3 (0.42) | ASIC3 | |
| SCHEMBL17963969 | 0.73 | HSD11B1 (0.42) | SCN9ASCN5AJAK2TYK2ASIC3 | |
| SCHEMBL17974204 | 0.73 | ROCK1 (0.47) | SCN9AROCK1TNFEGFRASIC3 | |
| SCHEMBL30824385 | 0.72 | TNF (0.51) | TNFFADS1EGFRSCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016120808-A1 | HETEROARYLAMINOISOQUINOLINES, METHODS FOR THEIR PREPARATION AND THERAPEUTIC USES THEREOF | MINORYX THERAPEUTICS S.L. (ES) | 2016-08-04 | — | — | WO | disclosed |