Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 6/20 | 0.42 |
| ▸ | CA9 | Q16790 | 6/20 | 0.42 |
| ▸ | CA12 | O43570 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 5/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17978552 | 1.00 | CYP19A1 (0.45) | CYP19A1AMY1ACA2CA9CA12 | |
| SCHEMBL17978555 | 0.91 | CYP19A1 (0.44) | CYP19A1AMY1ACA2CA9CA12 | |
| SCHEMBL1607272 | 0.77 | CA12 (0.47) | CA2CA9CA12CA1CA5A | |
| SCHEMBL5924217 | 0.73 | CA12 (0.61) | CA2CA9CA12CA1NOTUM | |
| SCHEMBL8665553 | 0.73 | ALDH1A1 (0.44) | CYP19A1POLBMAPT | |
| SCHEMBL8665555 | 0.73 | ALDH1A1 (0.44) | CYP19A1POLBMAPT | |
| SCHEMBL283802 | 0.72 | CYP1A2 (0.48) | POLBMAPT | |
| SCHEMBL283799 | 0.72 | CYP1A2 (0.48) | POLBMAPT | |
| SCHEMBL17978570 | 0.71 | PTGS2 (0.50) | CYP19A1AMY1ACA2CA9CA12 | |
| SCHEMBL1674057 | 0.71 | AMY1A (0.56) | CYP19A1AMY1ACA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3432881-A1 | USE OF DDX3 INHIBITORS AS ANTIPROLIFERATIVE AGENTS | Azienda Ospedaliera Universitaria Senese (IT) | 2019-01-30 | — | — | EP | disclosed |
| EP-3256461-A1 | HUMAN HELICASE DDX3 INHIBITORS AS THERAPEUTIC AGENTS | Azienda Ospedaliera Universitaria Senese (IT) | 2017-12-20 | — | — | EP | disclosed |
| WO-2017162834-A1 | USE OF DDX3 INHIBITORS AS ANTIPROLIFERATIVE AGENTS | AZIENDA OSPEDALIERA UNIVERSITARIA SENESE (IT) | 2017-09-28 | — | — | WO | disclosed |
| WO-2016128541-A1 | HUMAN HELICASE DDX3 INHIBITORS AS THERAPEUTIC AGENTS | AZIENDA OSPEDALIERA UNIVERSITARIA SENESE (IT) | 2016-08-18 | — | — | WO | disclosed |