Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL190518 | 0.79 | PLAAT3 (0.48) | RAB9AALDH1A1GAANPC1TSHR | |
| SCHEMBL2017242 | 0.78 | TSHR (0.39) | ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL1163924 | 0.76 | ALKBH1 (0.47) | ALDH1A1PKMNPC1TSHRL3MBTL1 | |
| SCHEMBL11306777 | 0.76 | HTR7 (0.51) | ALDH1A1DRD2DRD4DRD3 | |
| SCHEMBL16885185 | 0.76 | NUDT1 (0.37) | RAB9AMAPTALDH1A1LMNANPC1 | |
| SCHEMBL2014330 | 0.76 | RECQL (0.38) | ALDH1A1RECQL | |
| SCHEMBL3059054 | 0.76 | MAPT (0.36) | MAPTGAAL3MBTL1 | |
| SCHEMBL17898216 | 0.75 | KCNH2 (0.61) | KCNA3RAB9AMAPTNPC1TSHR | |
| SCHEMBL10643248 | 0.74 | KCNA3 (0.50) | KCNA3RAB9AMAPTALDH1A1TAAR1 | |
| SCHEMBL22576250 | 0.74 | MAPT (0.44) | MAPTALDH1A1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399948-B2 | Negative allosteric modulators of metabotropic glutamate receptor 3 | VANDERBILT UNIVERSITY (US) | 2019-09-03 | — | — | US | disclosed |
| US-10399948-B2 | Negative allosteric modulators of metabotropic glutamate receptor 3 | VANDERBILT UNIVERSITY (US) | 2019-09-03 | — | — | US | disclosed |
| US-20180022712-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 3 | VANDERBILT UNIVERSITY | 2018-01-25 | — | — | US | disclosed |
| US-20180022712-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 3 | VANDERBILT UNIVERSITY | 2018-01-25 | — | — | US | disclosed |
| WO-2016130652-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 3 | VANDERBILT UNIVERSITY (US) | 2016-08-18 | — | — | WO | disclosed |
| WO-2016130652-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 3 | VANDERBILT UNIVERSITY (US) | 2016-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180022712-A1 | NEGATIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR 3 | GRM3, GRM1, GRIN3A | KCNA3 633/4885RAB9A 1329/4885MAPT 277/4885 |
| US-10399948-B2 | Negative allosteric modulators of metabotropic glutamate receptor 3 | GRM3, GRM1, GRIN3A | KCNA3 633/4885RAB9A 1329/4885MAPT 277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.