Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 5/20 | 0.46 |
| ▸ | CLK1 | P49759 | 3/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17980470 | 0.84 | NR3C1 (0.56) | AHRKDRMETNR3C1 | |
| SCHEMBL17982124 | 0.77 | NR3C1 (0.52) | NR3C1 | |
| SCHEMBL12563103 | 0.73 | PRKCI (0.54) | KDR | |
| SCHEMBL19986926 | 0.73 | CSK (0.41) | METDYRK1A | |
| SCHEMBL17980461 | 0.71 | ATF1 (0.57) | NR3C1 | |
| SCHEMBL23657481 | 0.70 | LMNA (0.66) | NPC1TSHRALDH1A1 | |
| SCHEMBL17963260 | 0.70 | NR3C1 (0.77) | NR3C1 | |
| SCHEMBL30985188 | 0.70 | AXL (0.55) | — | |
| SCHEMBL2115690 | 0.70 | AXL (0.55) | — | |
| SCHEMBL27939132 | 0.69 | AXL (0.46) | KDRMETDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016123392-A2 | PYRAZOLOPYRIMIDINES AS INHIBITORS OF GLUCOCORTICOID RECEPTOR TRANSLOCATION | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2016-08-04 | — | — | WO | disclosed |