Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSK | P41240 | 5/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 4/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.37 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.37 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.37 |
| ▸ | ABL2 | P42684 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | BMX | P51813 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12518523 | 0.75 | LCK (0.64) | CSKMAP3K20DDR1MAPK14RAF1 | |
| SCHEMBL17980480 | 0.73 | AHR (0.48) | DYRK1AMET | |
| SCHEMBL14027871 | 0.70 | JAK1 (0.42) | BRAF | |
| SCHEMBL4789344 | 0.70 | AXL (0.48) | RAF1METBRAF | |
| SCHEMBL4789712 | 0.68 | BMX (0.49) | BMX | |
| SCHEMBL16588527 | 0.68 | PRKCI (0.59) | CSKMAP3K20MAPK14 | |
| SCHEMBL19724259 | 0.67 | HDAC1 (0.50) | MAPK14KDM4E | |
| SCHEMBL4789715 | 0.67 | BMX (0.58) | CSKMAP3K20DYRK1AMAPK14MAP4K2 | |
| SCHEMBL14026833 | 0.67 | BRAF (0.42) | RAF1KDM4EMETBRAF | |
| SCHEMBL2286190 | 0.66 | CSK (0.60) | CSKMAP3K20DDR1MAPK14MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2937345-B1 | TYPE II RAF KINASE INHIBITORS | DANA FARBER CANCER INST INC (US) | 2018-03-21 | — | — | EP | disclosed |