Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 11/20 | 0.55 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5111726 | 0.85 | PDE7A (0.74) | PDE7APDE7BSMN1; SMN2SLC6A4LMNA | |
| SCHEMBL1342485 | 0.82 | PDE7A (0.64) | PDE7APDE7BSMN1; SMN2SLC6A4LMNA | |
| SCHEMBL13236392 | 0.82 | PDE7A (0.70) | PDE7APDE7BSMN1; SMN2SLC6A4LMNA | |
| SCHEMBL2003379 | 0.76 | SLC6A2 (0.40) | SMN1; SMN2SLC6A4LMNAPOLBALDH1A1 | |
| SCHEMBL2960424 | 0.73 | SLC6A4 (0.61) | PDE7APDE7BSMN1; SMN2SLC6A4LMNA | |
| SCHEMBL29399835 | 0.73 | TDP1 (0.64) | MAPTPKMATMTDP1ALDH1A1 | |
| SCHEMBL6619 | 0.73 | TDP1 (0.64) | MAPTPKMATMTDP1ALDH1A1 | |
| SCHEMBL17985415 | 0.73 | SLC6A4 (0.38) | PDE7ASMN1; SMN2SLC6A4MAPTMEN1 | |
| SCHEMBL8381179 | 0.73 | PDE7A (0.43) | PDE7APDE7BSMN1; SMN2MAPTMEN1 | |
| SCHEMBL1340757 | 0.73 | PDE7A (0.55) | PDE7APDE7BSMN1; SMN2SLC6A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170296682-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-10-19 | — | — | US | disclosed |
| US-20170296682-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-10-19 | — | — | US | disclosed |
| US-20170296682-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2017-10-19 | — | — | US | disclosed |
| US-20160235869-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-08-18 | — | — | US | disclosed |
| US-20160235869-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-08-18 | — | — | US | disclosed |
| US-20160235869-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | THE JOHNS HOPKINS UNIVERSITY (US) | 2016-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170296682-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA7, CHRNB2, CHRNB3 | PDE7A 43/4885PDE7B 98/4885SMN1; SMN2 1145/4885 |
| US-20160235869-A1 | DERIVATIVES OF DIBENZOTHIOPHENE IMAGING OF alpha-7 NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA7, CHRNB2, CHRNB3 | PDE7A 43/4885PDE7B 98/4885SMN1; SMN2 1145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.