Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | S100A4 | P26447 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ESPL1 | Q14674 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29399835 | 1.00 | TDP1 (0.64) | TDP1ATMALDH1A1HIF1AS100A4 | |
| Ethylene SCHEMBL27608389 | 0.96 | TDP1 (0.60) | TDP1ATMALDH1A1HIF1AS100A4 | |
| SCHEMBL29172784 | 0.85 | ATM (0.49) | TDP1ATMALDH1A1HIF1AS100A4 | |
| SCHEMBL29429960 | 0.83 | ALDH1A1 (0.62) | TDP1ATMALDH1A1HIF1AS100A4 | |
| SCHEMBL40706 | 0.83 | ALDH1A1 (0.62) | TDP1ATMALDH1A1HIF1AS100A4 | |
| SCHEMBL28871017 | 0.81 | TDP1 (0.50) | TDP1ATMALDH1A1HIF1AS100A4 | |
| SCHEMBL1561802 | 0.80 | TSHR (0.56) | TDP1ATMALDH1A1S100A4TRPV1 | |
| SCHEMBL165733 | 0.78 | CYP19A1 (0.49) | TDP1ATMALDH1A1S100A4TRPV1 | |
| SCHEMBL29431838 | 0.78 | CYP19A1 (0.49) | TDP1ATMALDH1A1S100A4TRPV1 | |
| SCHEMBL29385912 | 0.78 | TDP1 (1.00) | TDP1ATMALDH1A1HIF1AVCAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2160 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115124470-B | Method for preparing sulfonamide structured kinase inhibitors | 奥瑞基尼肿瘤有限公司 | 2024-08-27 | — | — | CN | claimed |
| CN-116854670-A | Dihydroquinoxaline selective bromodomain recognition protein inhibitor, and preparation method and application thereof | 中国科学院上海药物研究所 | 2023-10-10 | — | — | CN | claimed |
| EP-4137487-A1 | PROCESS FOR THE PREPARATION OF A SULFONAMIDE STRUCTURED KINASE INHIBITOR | Aurigene Discovery Technologies Limited (IN) | 2023-02-22 | — | — | EP | claimed |
| EP-3601262-B1 | PROCESS FOR THE PREPARATION OF A SULFONAMIDE STRUCTURED KINASE INHIBITOR | AURIGENE DISCOVERY TECH LTD (IN) | 2022-11-09 | — | — | EP | claimed |
| CN-110446704-B | Process for the preparation of sulfonamide-structured kinase inhibitors | 奥赖恩公司 | 2022-07-05 | — | — | CN | claimed |
| US-11332460-B2 | Process for the preparation of a sulfonamide structured kinase inhibitor | ORION CORPORATION (FI) | 2022-05-17 | — | — | US | claimed |
| US-20210139462-A1 | PROCESS FOR THE PREPARATION OF A SULFONAMIDE STRUCTURED KINASE INHIBITOR | AURIGENE ONCOLOGY LIMITED (IN) | 2021-05-13 | — | — | US | claimed |
| US-10870637-B2 | Process for the preparation of a sulfonamide structured kinase inhibitor | ORION CORPORATION (FI) | 2020-12-22 | — | — | US | claimed |
| CN-110551101-B | 1. 6-disubstituted-benzo five-membered heterocyclic derivative and application thereof | 沈阳药科大学 | 2020-11-24 | — | — | CN | claimed |
| US-20200102291-A1 | PROCESS FOR THE PREPARATION OF A SULFONAMIDE STRUCTURED KINASE INHIBITOR | AURIGENE ONCOLOGY LIMITED (IN) | 2020-04-02 | — | — | US | claimed |
| CN-109354569-A | A kind of preparation method of the bromo- 4- fluorobenzene of 1,3- bis- | 常州大学 | 2019-02-19 | — | — | CN | claimed |
| WO-2018172616-A1 | PROCESS FOR THE PREPARATION OF A SULFONAMIDE STRUCTURED KINASE INHIBITOR | ORION CORPORATION (FI) | 2018-09-27 | — | — | WO | claimed |
| CN-108126656-A | For the modified activated carbon absorbent of benzene in Adsorption wastewater from chemical industry | 北京益清源环保科技有限公司 | 2018-06-08 | — | — | CN | claimed |
| US-20160362382-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2016-12-15 | — | — | US | claimed |
| US-9464059-B2 | Benzamide derivatives | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2016-10-11 | — | — | US | claimed |
| US-20150284336-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL DRUG DEVELOPMENT, LLC | 2015-10-08 | — | — | US | claimed |
| EP-2445345-B1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RES INST (US) | 2014-08-27 | — | — | EP | claimed |
| US-20120142922-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2012-06-07 | — | — | US | claimed |
| EP-2445345-A1 | BENZAMIDE DERIVATIVES | The Translational Genomics Research Institute (US) | 2012-05-02 | — | — | EP | claimed |
| WO-2010151441-A1 | BENZAMIDE DERIVATIVES | TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (US) | 2010-12-29 | — | — | WO | claimed |