Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Doxribtimine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | TK1 | P04183 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | ALB | P02768 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TK2 | O00142 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Doxribtimine SCHEMBL341619 | 0.95 | LMNA (0.59) | LMNATK1TSHRALBPKM | |
| Doxribtimine SCHEMBL2164592 | 0.89 | TK1 (0.53) | LMNATK1TSHRALBPKM | |
| Doxribtimine SCHEMBL9465657 | 0.87 | TK1 (0.51) | LMNATK1TSHRALBPKM | |
| Doxribtimine SCHEMBL8366525 | 0.85 | TK1 (0.53) | LMNATK1TSHRALBPKM | |
| Doxribtimine SCHEMBL1052084 | 0.85 | TK1 (0.52) | LMNATK1TSHRALBPKM | |
| Doxribtimine SCHEMBL1164058 | 0.85 | TK1 (0.53) | LMNATK1TSHRALBPKM | |
| Doxribtimine SCHEMBL3166229 | 0.85 | TK1 (0.52) | LMNATK1TSHRALBPKM | |
| Doxribtimine SCHEMBL3155784 | 0.85 | TK1 (0.52) | LMNATK1TSHRALBPKM | |
| Doxribtimine SCHEMBL28237206 | 0.84 | LMNA (0.51) | LMNATK1TSHRALBPKM | |
| Doxribtimine SCHEMBL2195275 | 0.83 | TK1 (0.52) | LMNATK1TSHRALBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10676772-B2 | Control of protein glycosylation by culture medium supplementation and cell culture process parameters | BIOGEN MA INC. (US) | 2020-06-09 | — | — | US | disclosed |
| US-20190085369-A1 | CONTROL OF PROTEIN GLYCOSYLATION BY CULTURE MEDIUM SUPPLEMENTATION AND CELL CULTURE PROCESS PARAMETERS | BIOGEN MA INC. (US) | 2019-03-21 | — | — | US | disclosed |
| US-9944968-B2 | Control of protein glycosylation by culture medium supplementation and cell culture process parameters | BIOGEN MA INC. (US) | 2018-04-17 | — | — | US | disclosed |
| US-20160304928-A1 | Control of Protein Glycosylation by Culture Medium Supplementation and Cell Culture Process Parameters | BIOGEN MA INC. (US) | 2016-10-20 | — | — | US | disclosed |
| US-20160237399-A1 | Control of Protein Glycosylation by Culture Medium Supplementation and Cell Culture Process Parameters | BIOGEN MA INC. (US) | 2016-08-18 | — | — | US | disclosed |