Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 4/20 | 0.69 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20428044 | 0.88 | CYP11B1 (0.55) | CYP11B1CYP11B2ALDH1A1MEN1KMT2A | |
| SCHEMBL229001 | 0.84 | LMNA (0.59) | CYP11B1CYP11B2ALDH1A1MEN1KMT2A | |
| SCHEMBL10129568 | 0.80 | CYP17A1 (0.45) | CYP11B1CYP11B2ALDH1A1MEN1KMT2A | |
| SCHEMBL5205094 | 0.78 | MEN1 (0.44) | CYP11B1CYP11B2ALDH1A1MEN1KMT2A | |
| SCHEMBL19911313 | 0.78 | CYP11B1 (0.41) | CYP11B1CYP11B2ALDH1A1MEN1KMT2A | |
| SCHEMBL19848066 | 0.77 | TLR8 (0.43) | CYP11B1CYP11B2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9570033 | 0.75 | TDP1 (0.44) | CYP11B1CYP11B2ALDH1A1MEN1KMT2A | |
| SCHEMBL19848365 | 0.75 | TRPM5 (0.42) | CYP11B1CYP11B2ALDH1A1MEN1KMT2A | |
| SCHEMBL9597264 | 0.75 | TRPM5 (0.44) | CYP11B1CYP11B2LMNASMN1; SMN2HTT | |
| SCHEMBL19848357 | 0.74 | CYP17A1 (0.64) | CYP11B1CYP11B2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160222011-A1 | COMT Inhibiting Methods and Compositions | LIEBER INSTITUTE, INC. | 2016-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160222011-A1 | COMT Inhibiting Methods and Compositions | COMT, SLC6A3, MAOA | CYP11B1 35/4885CYP11B2 65/4885ALDH1A1 79/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.