Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | USP1 | O94782 | 2/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.33 |
| ▸ | RHEB | Q15382 | 1/20 | 0.30 |
| ▸ | MLYCD | O95822 | 1/20 | 0.30 |
| ▸ | ESRRG | P62508 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.30 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17987405 | 0.85 | CYP11B2 (0.56) | CYP11B2HDAC4MEN1ALDH1A1KMT2A | |
| SCHEMBL17963580 | 0.83 | ALDH1A1 (0.41) | MEN1ALDH1A1KMT2A | |
| SCHEMBL17987307 | 0.82 | ALDH1A1 (0.41) | MEN1ALDH1A1KMT2A | |
| SCHEMBL17963588 | 0.78 | MEN1 (0.40) | CYP11B2MEN1ALDH1A1KMT2APDK2 | |
| SCHEMBL17987297 | 0.75 | ALDH1A1 (0.52) | CYP11B2HDAC4MEN1ALDH1A1KMT2A | |
| SCHEMBL17987314 | 0.74 | PLA2G2A (0.42) | MEN1ALDH1A1KMT2A | |
| SCHEMBL20547143 | 0.74 | CYP11B2 (0.47) | CYP11B2MEN1ALDH1A1KMT2A | |
| SCHEMBL17987406 | 0.74 | ALDH1A1 (0.49) | CYP11B2HDAC4MEN1ALDH1A1KMT2A | |
| SCHEMBL17987298 | 0.74 | ALDH1A1 (0.53) | CYP11B2MEN1ALDH1A1KMT2AHDAC6 | |
| SCHEMBL17987302 | 0.73 | ALDH1A1 (0.50) | CYP11B2HDAC4MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250569-B1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-01-09 | — | — | EP | disclosed |
| EP-3250569-B1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-01-09 | — | — | EP | disclosed |
| US-10131642-B1 | Aldosterone synthase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-11-20 | — | — | US | disclosed |
| US-20180312475-A1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-11-01 | — | — | US | disclosed |
| WO-2016123275-A1 | ALDOSTERONE SYNTHASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180312475-A1 | ALDOSTERONE SYNTHASE INHIBITORS | CYP21A2, CYP11B1, CYP17A1 | CYP11B2 5/4885HDAC4 2735/4885MEN1 610/4885 |
| US-10131642-B1 | Aldosterone synthase inhibitors | CYP21A2, CYP11B1, CYP17A1 | CYP11B2 5/4885HDAC4 2735/4885MEN1 610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.