Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 3/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.38 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.37 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.37 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14699619 | 0.80 | MAPT (0.55) | NPC1MAPTRAB9ALMNAESR1 | |
| SCHEMBL12817727 | 0.80 | MAPT (0.55) | NPC1MAPTRAB9ALMNAESR1 | |
| SCHEMBL17988687 | 0.80 | ACHE (0.50) | ACHEHSD17B1HSD17B2LMNAESR1 | |
| SCHEMBL17991982 | 0.79 | MAPT (0.44) | ACHENPC1MAPTRAB9ALMNA | |
| SCHEMBL17988682 | 0.78 | FASN (0.51) | NPC1MAPTRAB9AHSD17B1HSD17B2 | |
| SCHEMBL29748711 | 0.78 | HSD17B1 (0.59) | ACHEHSD17B1HSD17B2LMNAESR1 | |
| SCHEMBL27661242 | 0.78 | HSD17B1 (0.59) | ACHEHSD17B1HSD17B2LMNAESR1 | |
| SCHEMBL14699621 | 0.77 | RAB9A (0.55) | NPC1MAPTRAB9ALMNAALDH1A1 | |
| SCHEMBL17988727 | 0.77 | ALDH1A1 (0.61) | NPC1MAPTRAB9ALMNAALDH1A1 | |
| SCHEMBL14699617 | 0.77 | MAPT (0.55) | NPC1MAPTRAB9ALMNAESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9409859-B2 | Substituted diphenyl derivatives | CREATIVE THERAPEUTICS GMBH (DE) | 2016-08-09 | — | — | US | disclosed |