Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.58 |
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | NPC1 | O15118 | 7/20 | 0.58 |
| ▸ | KIF11 | P52732 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | XDH | P47989 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | IL2 | P60568 | 2/20 | 0.48 |
| ▸ | BCL2 | P10415 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17991978 | 0.93 | MAPT (0.50) | MAPTRAB9ANPC1KIF11KDM4E | |
| SCHEMBL17991989 | 0.92 | MAPT (0.61) | MAPTRAB9ANPC1KIF11KDM4E | |
| SCHEMBL15398655 | 0.90 | MAPT (0.58) | MAPTRAB9ANPC1KIF11KDM4E | |
| SCHEMBL17992013 | 0.83 | MAPT (0.53) | MAPTRAB9ANPC1KIF11KDM4E | |
| SCHEMBL15399462 | 0.83 | STS (0.63) | MAPTRAB9ANPC1KIF11KDM4E | |
| SCHEMBL17991988 | 0.81 | STS (0.51) | MAPTRAB9ANPC1KIF11KDM4E | |
| SCHEMBL17988703 | 0.81 | MIF (0.51) | MAPTRAB9ANPC1KIF11KDM4E | |
| SCHEMBL17988696 | 0.81 | ALOX12 (0.47) | MAPTRAB9ANPC1KIF11KDM4E | |
| SCHEMBL17988697 | 0.80 | MAPT (0.53) | MAPTRAB9ANPC1KIF11KDM4E | |
| SCHEMBL3355210 | 0.80 | STS (0.65) | MAPTRAB9ANPC1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9409859-B2 | Substituted diphenyl derivatives | CREATIVE THERAPEUTICS GMBH (DE) | 2016-08-09 | — | — | US | disclosed |