Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19731968 | 0.94 | GABRP (0.35) | HPGDPOLBFLT3ALDH1A1KDM4E | |
| SCHEMBL12800969 | 0.93 | CHEK2 (0.33) | HPGDPOLBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL17993513 | 0.92 | TP53 (0.38) | HPGDPOLBFLT3KDM4ESMN1; SMN2 | |
| SCHEMBL12800986 | 0.91 | GABRP (0.37) | HPGDPOLBALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL19521865 | 0.91 | KDM4E (0.36) | HPGDPOLBFLT3ALDH1A1KDM4E | |
| SCHEMBL21412960 | 0.90 | HPGD (0.34) | HPGDPOLBFLT3ALDH1A1KDM4E | |
| SCHEMBL16388451 | 0.90 | ALDH1A1 (0.33) | HPGDFLT3ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL19275393 | 0.90 | PDE10A (0.36) | HPGDPOLBKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL12800973 | 0.89 | ADORA2B (0.33) | HPGDALDH1A1KDM4EPIK3CDPIK3CA | |
| SCHEMBL12800967 | 0.89 | CHEK2 (0.33) | HPGDPOLBALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054498-B1 | BISIMIDAZODIAZOCINES | IDEMITSU KOSAN CO (JP) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016125110-A1 | BISIMIDAZOLODIAZOCINES | IDEMITSU KOSAN CO., LTD. (JP) | 2016-08-11 | — | — | WO | disclosed |
| EP-3054498-A1 | Bisimidazodiazocines | Idemitsu Kosan Co., Ltd. (JP) | 2016-08-10 | — | — | EP | disclosed |