Sugi Predict

Sugi Predict / Compounds / SCHEMBL18004154

SCHEMBL18004154

SCHEMBL18004154

COc1cc(OC)c(Cl)c(NCc2cnc(Cl)cc2Cl)c1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE5A O76074 2/20 0.38
▸ MAPK1 P28482 2/20 0.36
▸ ALDH1A1 P00352 2/20 0.36
▸ KDM4E B2RXH2 1/20 0.36
▸ DHFR P00374 1/20 0.35
▸ PGK1 P00558 2/20 0.35
▸ GSK3B P49841 1/20 0.35
▸ MAP4K2 Q12851 1/20 0.35
▸ CYP1A2 P05177 3/20 0.35
▸ CYP3A4 P08684 3/20 0.35
▸ CYP2D6 P10635 3/20 0.35
▸ TSHR P16473 3/20 0.35
▸ CYP2C19 P33261 3/20 0.35
▸ HIF1A Q16665 2/20 0.35
▸ TP53 P04637 1/20 0.35
▸ CLK4 Q9HAZ1 1/20 0.35
▸ ALOX15 P16050 1/20 0.35
▸ CYP2C9 P11712 1/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ TDP1 Q9NUW8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16176863 0.86 PDE5A (0.36) PDE5AMAPK1ALDH1A1KDM4EDHFR
SCHEMBL29940550 0.86 PDE5A (0.36) PDE5AMAPK1ALDH1A1KDM4EDHFR
SCHEMBL30261950 0.79 ALDH1A1 (0.41) PDE5AMAPK1ALDH1A1KDM4EDHFR
SCHEMBL18131699 0.78 KDM4E (0.53) MAPK1ALDH1A1KDM4EPLK1NPC1
SCHEMBL24195861 0.75 DHFR (0.48) ALDH1A1DHFRCYP1A2CYP3A4CYP2D6
SCHEMBL18004149 0.74 SLC6A4 (0.42) PDE5AMAPK1ALDH1A1KDM4EDHFR
SCHEMBL16176631 0.73 SLC6A4 (0.34) PDE5AMAPK1DHFRTSHRCYP2C9
SCHEMBL28593042 0.72 DHFR (0.36) ALDH1A1KDM4EDHFRHSD17B10
SCHEMBL30570470 0.71 SLC6A4 (0.44) CYP2D6SLC6A2SLC6A4
SCHEMBL23066496 0.71 SLC6A4 (0.44) CYP2D6SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113024547-B Bicyclic heterocycles as FGFR4 inhibitors 因赛特控股公司 2023-07-21 — — CN disclosed
US-11667635-B2 Bicyclic heterocycles as FGFR4 inhibitors INCYTE CORPORATION (US) 2023-06-06 — — US disclosed
WO-2023039828-A1 FUSED RING COMPOUNDS AS INHIBITORS OF FGFR4 TYROSINE KINASES NUTSHELL BIOTECH (SHANGHAI) CO., LTD. (CN) 2023-03-23 — — WO disclosed
US-20220009921-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS INCYTE CORPORATION 2022-01-13 — — US disclosed
CN-113024547-A Bicyclic heterocycles as FGFR4 inhibitors 因赛特公司 2021-06-25 — — CN disclosed
US-11014923-B2 Bicyclic heterocycles as FGFR4 inhibitors INCYTE CORPORATION (US) 2021-05-25 — — US disclosed
US-11014923-B2 Bicyclic heterocycles as FGFR4 inhibitors INCYTE CORPORATION (US) 2021-05-25 — — US disclosed
CN-107438608-B Bicyclic heterocycles as FGFR4 inhibitors 因赛特公司 2021-02-05 — — CN disclosed
US-20200399267-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS INCYTE CORPORATION 2020-12-24 — — US disclosed
US-20200399267-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS INCYTE CORPORATION 2020-12-24 — — US disclosed
US-20190241560-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS INCYTE CORPORATION 2019-08-08 — — US disclosed
US-20180244672-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS INCYTE CORPORATION 2018-08-30 — — US disclosed
US-9890156-B2 Bicyclic heterocycles as FGFR4 inhibitors INCYTE CORPORATION (US) 2018-02-13 — — US disclosed
US-9890156-B2 Bicyclic heterocycles as FGFR4 inhibitors INCYTE CORPORATION (US) 2018-02-13 — — US disclosed
US-9890156-B2 Bicyclic heterocycles as FGFR4 inhibitors INCYTE CORPORATION (US) 2018-02-13 — — US disclosed
EP-3259270-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS Incyte Corporation (US) 2017-12-27 — — EP disclosed
WO-2016134314-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS INCYTE CORPORATION (US) 2016-08-25 — — WO disclosed
US-20160244448-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS INCYTE CORPORATION 2016-08-25 — — US disclosed
US-20160244448-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS INCYTE CORPORATION 2016-08-25 — — US disclosed
US-20160244448-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS INCYTE CORPORATION 2016-08-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160244448-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS FGFR4, FGFR1, FGFR3 PDE5A 4269/4885MAPK1 2292/4885ALDH1A1 901/4885
US-11014923-B2 Bicyclic heterocycles as FGFR4 inhibitors FGFR4, FGFR1, FGFR3 PDE5A 4269/4885MAPK1 2292/4885ALDH1A1 901/4885
US-20190241560-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS FGFR4, FGFR1, FGFR3 PDE5A 4269/4885MAPK1 2292/4885ALDH1A1 901/4885
US-11667635-B2 Bicyclic heterocycles as FGFR4 inhibitors FGFR4, FGFR1, FGFR3 PDE5A 4269/4885MAPK1 2292/4885ALDH1A1 901/4885
US-20220009921-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS FGFR4, FGFR1, FGFR3 PDE5A 4269/4885MAPK1 2292/4885ALDH1A1 901/4885
US-20180244672-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS FGFR4, FGFR1, FGFR3 PDE5A 4269/4885MAPK1 2292/4885ALDH1A1 901/4885
US-20200399267-A1 BICYCLIC HETEROCYCLES AS FGFR4 INHIBITORS FGFR4, FGFR1, FGFR3 PDE5A 4269/4885MAPK1 2292/4885ALDH1A1 901/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.