Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 5/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 4/20 | 0.35 |
| ▸ | IDH2 | P48735 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18004615 | 0.90 | CTSS (0.43) | TGFBR1IRAK4NOTUMCTSSSCN9A | |
| SCHEMBL16399530 | 0.88 | CTSS (0.44) | TGFBR1IRAK4NOTUMCTSSIDH1 | |
| SCHEMBL18004595 | 0.87 | SYK (0.37) | IRAK4NOTUMCTSSIDH1IDH2 | |
| SCHEMBL18004623 | 0.87 | IRAK4 (0.36) | TGFBR1IRAK4NOTUMCTSSIDH1 | |
| SCHEMBL18004612 | 0.84 | CTSS (0.39) | TGFBR1IRAK4NOTUMCTSSSCN9A | |
| SCHEMBL18004616 | 0.84 | ADORA2A (0.37) | IRAK4CTSSSCN9A | |
| SCHEMBL18004627 | 0.80 | IDH1 (0.39) | TGFBR1SCN9AIDH1IDH2 | |
| SCHEMBL18005109 | 0.80 | USP30 (0.35) | TGFBR1NOTUMP2RX7IDH1IDH2 | |
| SCHEMBL18004606 | 0.79 | CTSS (0.43) | TGFBR1IRAK4CTSSSCN9AIDH1 | |
| SCHEMBL16399081 | 0.79 | HDAC4 (0.38) | SCN9AIDH1IDH2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4219477-A1 | CYANOTRIAZOLE COMPOUNDS | Otsuka Pharmaceutical Co., Ltd. (JP) | 2023-08-02 | — | — | EP | disclosed |
| US-10626095-B2 | Cyanotriazole compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2020-04-21 | — | — | US | disclosed |
| US-20160229816-A1 | CYANOTRIAZOLE COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2016-08-11 | — | — | US | disclosed |
| US-20160229816-A1 | CYANOTRIAZOLE COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2016-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10626095-B2 | Cyanotriazole compounds | CS, PC, ACAT1 | TGFBR1 2745/4885IRAK4 2687/4885NOTUM 1379/4885 |
| US-20160229816-A1 | CYANOTRIAZOLE COMPOUNDS | CS, PC, ACAT1 | TGFBR1 2745/4885IRAK4 2687/4885NOTUM 1379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.