Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6695727 | 0.83 | MCL1 (0.47) | MCL1KDM4EALDH1A1HPGDGRIA1 | |
| SCHEMBL687843 | 0.81 | GRIA1 (0.58) | MCL1KDM4EALDH1A1HPGDGRIA1 | |
| SCHEMBL15758398 | 0.81 | GRIA1 (0.57) | MCL1KDM4EALDH1A1HPGDGRIA1 | |
| SCHEMBL15758399 | 0.78 | MCL1 (0.41) | MCL1KDM4EALDH1A1HPGDLRRK2 | |
| SCHEMBL18007256 | 0.76 | PTGS2 (0.38) | ALDH1A1HPGDMAPTKMT2APTGS1 | |
| SCHEMBL19411747 | 0.75 | MDM2 (0.49) | MCL1KDM4EALDH1A1HPGDGRIA1 | |
| SCHEMBL3667255 | 0.75 | PIM1 (0.41) | MCL1KDM4EALDH1A1HPGDGRIA1 | |
| SCHEMBL6693260 | 0.73 | MCL1 (0.42) | MCL1KDM4EALDH1A1HPGDGRIA1 | |
| SCHEMBL6698453 | 0.72 | GRIA1 (0.47) | MCL1KDM4EALDH1A1HPGDGRIA1 | |
| SCHEMBL1882884 | 0.72 | GRIA1 (0.47) | MCL1KDM4EALDH1A1HPGDGRIA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3259262-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL | Mapi Pharma Limited (IL) | 2017-12-27 | — | — | EP | disclosed |
| WO-2016132343-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL | MAPI PHARMA LTD. (IL) | 2016-08-25 | — | — | WO | disclosed |