Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 5/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.33 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.33 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18007231 | 0.79 | TNKS (0.37) | TNKSTNKS2ALDH1A1AURKAMAPT | |
| SCHEMBL18007259 | 0.76 | MCL1 (0.49) | PTGS2PTGS1TNKSALDH1A1HTT | |
| SCHEMBL18074847 | 0.69 | PTGS2 (0.52) | PTGS2PTGS1ALDH1A1HTTHSD17B10 | |
| SCHEMBL3323469 | 0.68 | GRIN2D (0.59) | ALDH1A1HTTHSD17B10MEN1KMT2A | |
| SCHEMBL2160705 | 0.68 | GRIN2D (0.59) | ALDH1A1HTTHSD17B10MEN1KMT2A | |
| SCHEMBL2160707 | 0.68 | GRIN2D (0.59) | ALDH1A1HTTHSD17B10MEN1KMT2A | |
| SCHEMBL37278 | 0.65 | PTGS2 (0.66) | PTGS2PTGS1ALDH1A1HTTHSD17B10 | |
| SCHEMBL30587086 | 0.65 | ALDH1A1 (0.50) | ALDH1A1HTTKCNN4HPGD | |
| SCHEMBL753524 | 0.65 | FGF23 (0.41) | PTGS2PTGS1ALDH1A1HTTHSD17B10 | |
| SCHEMBL21645885 | 0.65 | FGF23 (0.41) | PTGS2PTGS1ALDH1A1HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3259262-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL | Mapi Pharma Limited (IL) | 2017-12-27 | — | — | EP | disclosed |
| WO-2016132343-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PERAMPANEL | MAPI PHARMA LTD. (IL) | 2016-08-25 | — | — | WO | disclosed |