Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | TNKS | O95271 | 5/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | USP8 | P40818 | 1/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15758398 | 0.87 | GRIA1 (0.57) | MCL1KDM4EHPGDALDH1A1PIK3CD | |
| SCHEMBL687843 | 0.86 | GRIA1 (0.58) | MCL1KDM4EHPGDALDH1A1PIK3CD | |
| SCHEMBL18007259 | 0.83 | MCL1 (0.49) | MCL1KDM4EHPGDALDH1A1PIK3CD | |
| SCHEMBL6693260 | 0.79 | MCL1 (0.42) | MCL1KDM4EHPGDALDH1A1PIK3CD | |
| SCHEMBL6692469 | 0.78 | TNKS (0.44) | TNKSTNKS2 | |
| SCHEMBL6695728 | 0.74 | MCL1 (0.45) | MCL1KDM4EHPGDALDH1A1PIK3CD | |
| SCHEMBL6131063 | 0.71 | ESR2 (0.47) | HPGDALDH1A1PDE4DGRIA1GRIA3 | |
| SCHEMBL1882537 | 0.71 | GRIA1 (0.79) | KDM4EALDH1A1PDE4DGRIA1GRIA3 | |
| SCHEMBL16456315 | 0.71 | TNKS (0.52) | KDM4ETNKSTNKS2GAALMNA | |
| SCHEMBL10707443 | 0.70 | MCL1 (0.63) | MCL1KDM4EHPGDALDH1A1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465626-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | Eisai Co., Ltd. (JP) | 2004-10-13 | — | — | EP | disclosed |
| WO-2003047577-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING DIHYDROPYRIDINONE COMPOUNDS AND AN IMMUNOREGULATORY OR AN ANTIINFLAMMATORY AGENT AND THEIR USES | EISAI CO LTD (JP) | 2003-06-12 | — | — | WO | disclosed |