Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.65 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.65 |
| ▸ | NT5E | P21589 | 1/20 | 0.62 |
| ▸ | IMPDH2 | P12268 | 7/20 | 0.62 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.62 |
| ▸ | TGM2 | P21980 | 1/20 | 0.58 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.55 |
| ▸ | HINT1 | P49773 | 1/20 | 0.54 |
| ▸ | KRAS | P01116 | 5/20 | 0.54 |
| ▸ | RNASEL | Q05823 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25391360 | 0.90 | TAS1R3 (0.70) | TAS1R3TAS1R1NT5EIMPDH2IMPDH1 | |
| SCHEMBL720437 | 0.90 | TAS1R3 (0.70) | TAS1R3TAS1R1NT5EIMPDH2IMPDH1 | |
| SCHEMBL14576179 | 0.90 | TAS1R3 (0.70) | TAS1R3TAS1R1NT5EIMPDH2IMPDH1 | |
| SCHEMBL600378 | 0.90 | TAS1R3 (0.70) | TAS1R3TAS1R1NT5EIMPDH2IMPDH1 | |
| SCHEMBL26067681 | 0.90 | TAS1R3 (0.70) | TAS1R3TAS1R1NT5EIMPDH2IMPDH1 | |
| SCHEMBL843561 | 0.88 | TAS1R3 (0.68) | TAS1R3TAS1R1NT5EIMPDH2IMPDH1 | |
| SCHEMBL29260230 | 0.88 | TAS1R3 (0.68) | TAS1R3TAS1R1NT5EIMPDH2IMPDH1 | |
| SCHEMBL25525 | 0.88 | HPGD (0.56) | TAS1R3TAS1R1NT5ETGM2HINT1 | |
| SCHEMBL5661895 | 0.88 | HINT1 (0.55) | TAS1R3TAS1R1NT5EIMPDH2IMPDH1 | |
| SCHEMBL18007485 | 0.88 | TAS1R3 (0.68) | TAS1R3TAS1R1NT5EIMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250122505-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | BANK OF AMERICA, N.A. | 2025-04-17 | — | — | US | disclosed |
| US-11028392-B2 | Compositions and methods for inhibiting expression of the ALAS1 gene | ALNYLAM PHARMACEUTICALS, INC. (US) | 2021-06-08 | — | — | US | disclosed |
| EP-3693463-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | Alnylam Pharmaceuticals, Inc. (US) | 2020-08-12 | — | — | EP | disclosed |
| EP-3052628-B1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | ALNYLAM PHARMACEUTICALS INC (US) | 2020-02-26 | — | — | EP | disclosed |
| US-20190144870-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | BANK OF AMERICA, N.A. | 2019-05-16 | — | — | US | disclosed |
| US-10119143-B2 | Compositions and methods for inhibiting expression of the ALAS1 gene | ALNYLAM PHARMACEUTICALS, INC. (US) | 2018-11-06 | — | — | US | disclosed |
| US-20160244766-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | ALNYLAM PHARMACEUTICALS, INC. (US) | 2016-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160244766-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | AARS1, RNASE1, DDX39B | TAS1R3 2586/4885TAS1R1 2666/4885NT5E 2411/4885 |
| US-11028392-B2 | Compositions and methods for inhibiting expression of the ALAS1 gene | AARS1, RNASE1, DDX39B | TAS1R3 2586/4885TAS1R1 2666/4885NT5E 2411/4885 |
| US-20190144870-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | AARS1, RNASE1, DDX39B | TAS1R3 2586/4885TAS1R1 2666/4885NT5E 2411/4885 |
| US-10119143-B2 | Compositions and methods for inhibiting expression of the ALAS1 gene | AARS1, RNASE1, DDX39B | TAS1R3 2586/4885TAS1R1 2666/4885NT5E 2411/4885 |
| US-20250122505-A1 | COMPOSITIONS AND METHODS FOR INHIBITING EXPRESSION OF THE ALAS1 GENE | AARS1, RNASE1, DDX39B | TAS1R3 2586/4885TAS1R1 2666/4885NT5E 2411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.