Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16333898 | 0.88 | PDE4D (0.46) | LMNAPDE4DMRGPRX4HPGDHSD17B10 | |
| SCHEMBL18010709 | 0.88 | PDE4D (0.48) | LMNARAB9APDE4DHPGDHSD17B10 | |
| SCHEMBL28476882 | 0.85 | HTT (0.57) | TSHRLMNAMAPK1HTTRAB9A | |
| SCHEMBL4630412 | 0.85 | LMNA (0.48) | TSHRLMNAMAPK1HTTRAB9A | |
| SCHEMBL22394631 | 0.84 | TSHR (0.48) | TSHRLMNAMAPK1HTTRAB9A | |
| SCHEMBL16333650 | 0.83 | CDC25B (0.48) | LMNAHTTRAB9APDE4DMRGPRX4 | |
| SCHEMBL18151908 | 0.81 | RARB (0.46) | TSHRLMNAMAPK1HTTRAB9A | |
| SCHEMBL8128858 | 0.79 | HTT (0.54) | TSHRLMNAMAPK1HTTRAB9A | |
| SCHEMBL7334285 | 0.77 | CA12 (0.69) | TSHRHTTPDE4DHPGDHSD17B10 | |
| SCHEMBL177336 | 0.77 | TSHR (0.77) | TSHRMAPK1MRGPRX4HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10098975-B2 | Labeled pkg-1-alpha-binding compounds and their use in imaging and quantifying pain | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-10-16 | — | — | US | disclosed |
| EP-3013339-B1 | LABELED PKG-1-ALPHA-BINDING COMPOUNDS AND THEIR USE IN IMAGING AND QUANTIFYING PAIN | UNIV COLUMBIA (US) | 2018-09-12 | — | — | EP | disclosed |
| US-20160243266-A1 | Labeled pkg-1-alpha-binding compounds and their use in imaging and quantifying pain | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10098975-B2 | Labeled pkg-1-alpha-binding compounds and their use in imaging and quantifying pain | OPRK1, PKN1, PRKG1 | TSHR 2605/4885LMNA 2262/4885MAPK1 297/4885 |
| US-20160243266-A1 | Labeled pkg-1-alpha-binding compounds and their use in imaging and quantifying pain | OPRK1, PKN1, PRKG1 | TSHR 2605/4885LMNA 2262/4885MAPK1 297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.