Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.46 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.40 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18044460 | 0.90 | RARB (0.40) | RARBPOLBCASP6RARAALDH1A1 | |
| SCHEMBL18151941 | 0.90 | RARB (0.40) | RARBPOLBCASP6RARAALDH1A1 | |
| SCHEMBL18499050 | 0.90 | RARB (0.40) | RARBPOLBCASP6RARAALDH1A1 | |
| SCHEMBL18044448 | 0.89 | RARB (0.40) | RARBPLA2G2DPOLBCASP6RARA | |
| SCHEMBL16690678 | 0.89 | RARB (0.40) | RARBPLA2G2DPOLBCASP6RARA | |
| SCHEMBL18044454 | 0.88 | MAPT (0.43) | ALDH1A1HPGDLMNARAB9AKMT2A | |
| SCHEMBL20709061 | 0.87 | RXRA (0.35) | RARBPLA2G2DRARALMNA | |
| SCHEMBL20709124 | 0.86 | PDE4D (0.39) | RARBALDH1A1LMNA | |
| SCHEMBL20709028 | 0.83 | GAA (0.44) | RARBPTPN11RARALMNAMAPK1 | |
| SCHEMBL18010707 | 0.81 | TSHR (0.47) | PTPN11TSHRALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3067351-B1 | COMPOUND HAVING HIGHER INHIBITION OF PROTEIN KINASE G ACTIVITY AND PREPARATION METHOD THEREFOR | JENKEM TECH CO LTD TIANJIN (CN) | 2019-02-06 | — | — | EP | disclosed |
| EP-3067351-B1 | COMPOUND HAVING HIGHER INHIBITION OF PROTEIN KINASE G ACTIVITY AND PREPARATION METHOD THEREFOR | JENKEM TECH CO LTD TIANJIN (CN) | 2019-02-06 | — | — | EP | disclosed |
| US-9925171-B2 | Compound having higher inhibitory activity on protein kinase G and preparation method thereof | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2018-03-27 | — | — | US | disclosed |
| US-9925171-B2 | Compound having higher inhibitory activity on protein kinase G and preparation method thereof | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2018-03-27 | — | — | US | disclosed |
| US-9925171-B2 | Compound having higher inhibitory activity on protein kinase G and preparation method thereof | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2018-03-27 | — | — | US | disclosed |
| US-20170119736-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2017-05-04 | — | — | US | disclosed |
| US-20170119736-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2017-05-04 | — | — | US | disclosed |
| US-20170119736-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2017-05-04 | — | — | US | disclosed |
| US-9567319-B2 | Compound having higher inhibitory activity on protein kinase G and preparation method thereof | JENKEM TECHNOLOGY CO. LTD., (TIANJIN) (CN) | 2017-02-14 | — | — | US | disclosed |
| US-9567319-B2 | Compound having higher inhibitory activity on protein kinase G and preparation method thereof | JENKEM TECHNOLOGY CO. LTD., (TIANJIN) (CN) | 2017-02-14 | — | — | US | disclosed |
| US-9567319-B2 | Compound having higher inhibitory activity on protein kinase G and preparation method thereof | JENKEM TECHNOLOGY CO. LTD., (TIANJIN) (CN) | 2017-02-14 | — | — | US | disclosed |
| US-20160304501-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2016-10-20 | — | — | US | disclosed |
| US-20160304501-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2016-10-20 | — | — | US | disclosed |
| US-20160304501-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | Jenkem Technology Co., Ltd., (Tianjin) (CN) | 2016-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304501-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | PRKCG, PRKG2, PKN3 | RARB 4527/4885PLA2G2D 609/4885PTPN11 2194/4885 |
| US-20170119736-A1 | COMPOUND HAVING HIGHER INHIBITORY ACTIVITY ON PROTEIN KINASE G AND PREPARATION METHOD THEREOF | PRKCG, PRKG2, PKN3 | RARB 4527/4885PLA2G2D 609/4885PTPN11 2194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.