Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.49 |
| ▸ | NPC1 | O15118 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17437468 | 0.81 | RAB9A (0.35) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL25429336 | 0.72 | SMN1; SMN2 (0.56) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL9554794 | 0.69 | BCHE (0.54) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL12779078 | 0.69 | BACE1 (0.63) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL18321301 | 0.69 | EGLN1 (0.62) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL15246754 | 0.68 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| Hydrochloric Acid SCHEMBL18321261 | 0.68 | EGLN1 (0.60) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL3389271 | 0.67 | BCHE (0.56) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL20040367 | 0.67 | AURKA (0.69) | RAB9ANPC1SMN1; SMN2MAPTTP53 | |
| SCHEMBL861076 | 0.67 | ALDH1A1 (0.49) | RAB9ANPC1SMN1; SMN2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951957-B2 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG (CH) | 2011-05-31 | — | — | US | disclosed |
| EP-1723138-B1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE FOR INDUCING APOPTOSIS | BASILEA PHARMACEUTICA AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| US-20080287681-A1 | Substituted Benzimidazoles and their Use for Inducing Apoptosis | EBERLE MARTIN | 2008-11-20 | — | — | US | disclosed |
| US-7423157-B2 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG (CH) | 2008-09-09 | — | — | US | disclosed |
| US-20070167505-A1 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG | 2007-07-19 | — | — | US | disclosed |
| US-20070066670-A1 | Substituted benzimidazoles and their use for inducing apoptosis | BASILEA PHARMACEUTICA AG | 2007-03-22 | — | — | US | disclosed |
| EP-1723138-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE FOR INDUCING APOPTOSIS | Basilea Pharmaceutica AG (CH) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005077939-A1 | SUBSTITUTED BENZIMIDAZOLES AND THEIR USE FOR INDUCING APOPTOSIS | BASILEA PHARMACEUTICA AG (CH) | 2005-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167505-A1 | Substituted benzimidazoles and their use for inducing apoptosis | BAX, BCL2, BAD | RAB9A 4170/4885NPC1 3798/4885SMN1; SMN2 2693/4885 |
| US-20070066670-A1 | Substituted benzimidazoles and their use for inducing apoptosis | BAX, BCL2, BAD | RAB9A 4170/4885NPC1 3798/4885SMN1; SMN2 2693/4885 |
| US-20080287681-A1 | Substituted Benzimidazoles and their Use for Inducing Apoptosis | BAX, BCL2, BAD | RAB9A 4170/4885NPC1 3798/4885SMN1; SMN2 2693/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.