SCHEMBL1801255

SCHEMBL1801255

O=C1CC(c2ccccc2)N1C(=O)c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.57
ALDH1A1 P00352 3/20 0.55
RIPK1 Q13546 4/20 0.55
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
LMNA P02545 1/20 0.43
KDM4E B2RXH2 1/20 0.42
HTT P42858 1/20 0.42
ITGB1 P05556 1/20 0.42
ITGA5 P08648 1/20 0.42
HPGD P15428 1/20 0.42
TERT O14746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14568381 0.80 ALDH1A1 (0.49) L3MBTL1ALDH1A1MEN1KMT2AITGB1
SCHEMBL12620555 0.80 RIPK1 (0.56) L3MBTL1ALDH1A1RIPK1MEN1KMT2A
SCHEMBL30525266 0.78 LMNA (0.45) L3MBTL1ALDH1A1RIPK1MEN1KMT2A
SCHEMBL7545798 0.77 ALDH1A1 (0.47) L3MBTL1ALDH1A1RIPK1MEN1KMT2A
SCHEMBL19511247 0.76 RIPK1 (0.56) RIPK1KMT2ALMNAITGB1ITGA5
SCHEMBL7133590 0.74 RIPK1 (0.54) L3MBTL1ALDH1A1RIPK1MEN1KMT2A
SCHEMBL23758948 0.74 RIPK1 (0.52) L3MBTL1ALDH1A1RIPK1KMT2AITGB1
SCHEMBL26984284 0.73 P2RX7 (0.50) L3MBTL1ALDH1A1RIPK1MEN1KMT2A
SCHEMBL17870962 0.73 RIPK1 (0.52) L3MBTL1ALDH1A1RIPK1MEN1KMT2A
SCHEMBL19471101 0.73 RIPK1 (0.52) L3MBTL1ALDH1A1RIPK1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10736915-B2 Nylon-3 co-polymers and synthetic lung surfactant compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2020-08-11 US disclosed
US-10736915-B2 Nylon-3 co-polymers and synthetic lung surfactant compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2020-08-11 US disclosed
US-10323121-B2 Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2019-06-18 US disclosed
US-10323121-B2 Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2019-06-18 US disclosed
US-20180153928-A1 NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2018-06-07 US disclosed
US-20180153928-A1 NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2018-06-07 US disclosed
US-20180153928-A1 NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2018-06-07 US disclosed
US-9925213-B2 Nylon-3 co-polymers and synthetic lung surfactant compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2018-03-27 US disclosed
US-9925213-B2 Nylon-3 co-polymers and synthetic lung surfactant compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2018-03-27 US disclosed
US-9925213-B2 Nylon-3 co-polymers and synthetic lung surfactant compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2018-03-27 US disclosed
US-7951912-B2 Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2011-05-31 US disclosed
US-7951912-B2 Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2011-05-31 US disclosed
US-7951912-B2 Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2011-05-31 US disclosed
US-20100222250-A1 POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME WISCONSIN ALUMNI RESEARCH FOUNDATION 2010-09-02 US disclosed
US-20100222250-A1 POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME WISCONSIN ALUMNI RESEARCH FOUNDATION 2010-09-02 US disclosed
US-20100222250-A1 POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME WISCONSIN ALUMNI RESEARCH FOUNDATION 2010-09-02 US disclosed
US-20070087404-A1 Poly-beta-peptides from functionalized beta-lactam monomers and antibacterial compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION 2007-04-19 US disclosed
US-20070087404-A1 Poly-beta-peptides from functionalized beta-lactam monomers and antibacterial compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION 2007-04-19 US disclosed
US-20070087404-A1 Poly-beta-peptides from functionalized beta-lactam monomers and antibacterial compositions containing same WISCONSIN ALUMNI RESEARCH FOUNDATION 2007-04-19 US disclosed
WO-2007025141-A2 POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2007-03-01 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10736915-B2 Nylon-3 co-polymers and synthetic lung surfactant compositions containing same STARD3, SPTSSB, PLIN3 L3MBTL1 1713/4885ALDH1A1 4866/4885RIPK1 1318/4885
US-20180153928-A1 NYLON-3 CO-POLYMERS AND SYNTHETIC LUNG SURFACTANT COMPOSITIONS CONTAINING SAME STARD3, SPTSSB, PLIN3 L3MBTL1 1713/4885ALDH1A1 4866/4885RIPK1 1318/4885
US-10323121-B2 Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same TMSB10, TMSB4X, PTMA L3MBTL1 329/4885ALDH1A1 4846/4885RIPK1 2427/4885
US-20070087404-A1 Poly-beta-peptides from functionalized beta-lactam monomers and antibacterial compositions containing same TMSB10, TMSB4X, PTMA L3MBTL1 290/4885ALDH1A1 4840/4885RIPK1 2562/4885
US-20100222250-A1 POLY-BETA-PEPTIDES FROM FUNCTIONALIZED BETA-LACTAM MONOMERS AND ANTIBACTERIAL COMPOSITIONS CONTAINING SAME TMSB10, TMSB4X, PTMA L3MBTL1 290/4885ALDH1A1 4840/4885RIPK1 2562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.