Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 2/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7525226 | 1.00 | LMNA (0.54) | LMNAMAPK1CYP2D6SRCHIF1A | |
| SCHEMBL10024370 | 1.00 | LMNA (0.54) | LMNAMAPK1CYP2D6SRCHIF1A | |
| SCHEMBL28365109 | 0.87 | LMNA (0.50) | LMNAMAPK1CYP2D6SRCHIF1A | |
| SCHEMBL17093337 | 0.87 | LMNA (0.50) | LMNAMAPK1CYP2D6SRCHIF1A | |
| SCHEMBL16795921 | 0.87 | LMNA (0.50) | LMNAMAPK1CYP2D6SRCHIF1A | |
| SCHEMBL14960669 | 0.84 | HPGD (0.47) | LMNAMAPK1CYP2D6SRCHIF1A | |
| SCHEMBL8178447 | 0.83 | ALOX5 (0.48) | LMNAMAPK1CYP2D6SRCHIF1A | |
| Cadaverine Tartrate SCHEMBL27514487 | 0.82 | LMNA (0.54) | LMNAMAPK1CYP2D6SRCHIF1A | |
| SCHEMBL2175085 | 0.81 | CYP1A2 (0.46) | LMNAKDM4E | |
| SCHEMBL21200913 | 0.81 | CPN1 (0.54) | LMNAMAPK1HIF1AKDM4EPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402316-A1 | Piperidine derivatives | AstraZeneca AB (Publ) (SE) | 2012-01-04 | — | — | EP | disclosed |