Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | REN | P00797 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1019313 | 0.82 | PTK6 (0.45) | PIK3CAMTORPIK3CGRENHDAC1 | |
| SCHEMBL30066295 | 0.76 | GHSR (0.54) | HPGDALDH1A1 | |
| SCHEMBL1409459 | 0.76 | SIGMAR1 (0.68) | CA12CA1CA2CA7CA9 | |
| SCHEMBL15034004 | 0.75 | GRM5 (0.51) | CA12CA1CA2CA7CA9 | |
| SCHEMBL13724596 | 0.74 | CA12 (0.49) | CA12CA1CA2CA7CA9 | |
| SCHEMBL20261717 | 0.73 | CA12 (0.73) | CA12CA1CA2CA7CA9 | |
| SCHEMBL11710461 | 0.72 | PKM (0.47) | HPGDGABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL14320380 | 0.72 | GRM3 (0.58) | CA12CA1CA2CA7CA9 | |
| SCHEMBL14466291 | 0.71 | SIGMAR1 (0.60) | CA12CA1CA2CA7CA9 | |
| SCHEMBL18053942 | 0.71 | CHRM2 (0.52) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2625176-B1 | SUBSTITUTUTED 6-AMINO-PYRIDAZIN-3-YL-CARBOXAMIDE COMPOUNDS AS PROTEIN KINASE MODULATORS | XCOVERY HOLDING CO LLC (US) | 2016-08-17 | — | — | EP | disclosed |