Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | MITF | O75030 | 1/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.54 |
| ▸ | VCP | P55072 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.49 |
| ▸ | GALR2 | O43603 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 5/20 | 0.49 |
| ▸ | TLR4 | O00206 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1570297 | 1.00 | PRMT1 (0.54) | PRMT1MAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL34463030 | 0.88 | FBP1 (0.57) | PRMT1MAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL3100263 | 0.83 | CYP1A2 (0.66) | PRMT1MAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL3100253 | 0.83 | CYP1A2 (0.66) | PRMT1MAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL34462751 | 0.81 | PRMT1 (0.57) | PRMT1MAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL1569821 | 0.81 | PRMT1 (0.54) | PRMT1MAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL1804005 | 0.81 | PRMT1 (0.54) | PRMT1MAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL30823746 | 0.81 | PRMT1 (0.54) | PRMT1MAPTLMNAALDH1A1MAPK1 | |
| SCHEMBL1422411 | 0.79 | FBP1 (0.53) | PRMT1MAPTLMNAALDH1A1HTT | |
| SCHEMBL1422409 | 0.79 | FBP1 (0.53) | PRMT1MAPTLMNAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3144303-B1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC (US) | 2018-09-26 | — | — | EP | disclosed |
| EP-3144303-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | Array Biopharma, Inc. (US) | 2017-03-22 | — | — | EP | disclosed |
| US-9556139-B2 | 6-substituted phenoxychroman carboxylic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2017-01-31 | — | — | US | disclosed |
| EP-2826774-B1 | Intermediates for 6-substituted phenoxychroman carboxylic acid derivatives | ARRAY BIOPHARMA INC (US) | 2016-05-25 | — | — | EP | disclosed |
| US-20150232442-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC. (US) | 2015-08-20 | — | — | US | disclosed |
| US-9096567-B2 | 6-substituted phenoxychroman carboxylic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2015-08-04 | — | — | US | disclosed |
| EP-2826774-A1 | Intermediates for 6-substituted phenoxychroman carboxylic acid derivatives | Array Biopharma, Inc. (US) | 2015-01-21 | — | — | EP | disclosed |
| EP-2307397-B1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC (US) | 2014-08-20 | — | — | EP | disclosed |
| US-20140221342-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-8716498-B2 | 6-substituted phenoxychroman carboxylic acid derivatives | ARRAY BIOPHARMA, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20140005418-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC. (US) | 2014-01-02 | — | — | US | disclosed |
| US-8569522-B2 | 6-substituted phenoxychroman carboxylic acid derivatives | ARRAY BIOPHARMA INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20110105463-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC. (US) | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221342-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | HRH1, HRH2, HRH4 | PRMT1 2736/4885MAPT 2370/4885LMNA 3185/4885 |
| US-20110105463-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | GPR52, CD22, CD4 | PRMT1 672/4885MAPT 4698/4885LMNA 3052/4885 |
| US-20150232442-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | GPR52, CD22, CD74 | PRMT1 738/4885MAPT 4791/4885LMNA 3072/4885 |
| US-20140005418-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | UGT1A6, UGT2B7, UGT1A7 | PRMT1 2401/4885MAPT 3206/4885LMNA 1257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.