Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | KDM5C | P41229 | 1/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | IDUA | P35475 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14129575 | 1.00 | ALDH1A1 (0.47) | ALDH1A1GAAKDM4ECTSDKDM5C | |
| SCHEMBL26667252 | 0.98 | ALDH1A1 (0.44) | ALDH1A1GAAKDM4ECTSDKDM5C | |
| SCHEMBL20773993 | 0.92 | KDM4E (0.41) | ALDH1A1GAAKDM4ECTSDKDM5C | |
| SCHEMBL14328132 | 0.82 | HDAC8 (0.60) | KDM4EHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL19079656 | 0.81 | CNR2 (0.42) | CNR2HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL25257297 | 0.79 | IDUA (0.38) | ALDH1A1KDM4ECNR2IDUALMNA | |
| SCHEMBL19194629 | 0.79 | IDUA (0.38) | ALDH1A1KDM4ECNR2IDUALMNA | |
| SCHEMBL30684791 | 0.79 | IDUA (0.38) | ALDH1A1KDM4ECNR2IDUALMNA | |
| SCHEMBL13772507 | 0.79 | IDUA (0.38) | ALDH1A1KDM4ECNR2IDUALMNA | |
| SCHEMBL18635573 | 0.79 | IDUA (0.38) | ALDH1A1KDM4ECNR2IDUALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110591078-B | Preparation method of reduction/pH dual-responsiveness adriamycin prodrug | 苏州大学 | 2021-11-05 | — | — | CN | claimed |
| CN-107233309-B | Mixed micelle medicine based on doxorubicin prodrug and gene co-loading and preparation method thereof | 苏州大学 | 2021-03-02 | — | — | CN | claimed |
| CN-110591078-A | Preparation method of reduction/pH dual-responsiveness adriamycin prodrug | 苏州大学 | 2019-12-20 | — | — | CN | claimed |
| US-11786525-B1 | High-efficiency anti-tumor nano-drug delivery system containing hydralazine and preparation method thereof | SHANGHAI INSTITUTE FOR ADVANCED STUDY ZHE JIANG UNIVERSITY (CN) | 2023-10-17 | — | — | US | disclosed |
| CN-115120573-B | High-efficiency anti-tumor nano drug-loading system containing hydralazine and preparation method thereof | 上海浙江大学高等研究院 | 2022-12-20 | — | — | CN | disclosed |
| CN-115120573-A | High-efficiency anti-tumor nano drug-loading system containing hydralazine and preparation method thereof | 上海浙江大学高等研究院 | 2022-09-30 | — | — | CN | disclosed |
| CN-110591078-B | Preparation method of reduction/pH dual-responsiveness adriamycin prodrug | 苏州大学 | 2021-11-05 | — | — | CN | disclosed |
| CN-107233309-B | Mixed micelle medicine based on doxorubicin prodrug and gene co-loading and preparation method thereof | 苏州大学 | 2021-03-02 | — | — | CN | disclosed |
| US-10632206-B2 | Zwitterionic polymers with therapeutic moieties | UNIVERSITY OF MASSACHUSETTS (US) | 2020-04-28 | — | — | US | disclosed |
| US-10632206-B2 | Zwitterionic polymers with therapeutic moieties | UNIVERSITY OF MASSACHUSETTS (US) | 2020-04-28 | — | — | US | disclosed |
| CN-110591078-A | Preparation method of reduction/pH dual-responsiveness adriamycin prodrug | 苏州大学 | 2019-12-20 | — | — | CN | disclosed |
| EP-2358770-B1 | ZWITTERIONIC POLYMERS WITH THERAPEUTIC MOIETIES | UNIV MASSACHUSETTS (US) | 2017-03-15 | — | — | EP | disclosed |
| US-20160346400-A1 | ZWITTERIONIC POLYMERS WITH THERAPEUTIC MOIETIES | UNIVERSITY OF MASSACHUSETTS | 2016-12-01 | — | — | US | disclosed |
| US-20160346400-A1 | ZWITTERIONIC POLYMERS WITH THERAPEUTIC MOIETIES | UNIVERSITY OF MASSACHUSETTS | 2016-12-01 | — | — | US | disclosed |
| US-9416210-B2 | Zwitterionic polymers with therapeutic moieties | THE UNIVERSITY OF MASSACHUSETTS (US) | 2016-08-16 | — | — | US | disclosed |
| US-9416210-B2 | Zwitterionic polymers with therapeutic moieties | THE UNIVERSITY OF MASSACHUSETTS (US) | 2016-08-16 | — | — | US | disclosed |
| US-20110319569-A1 | ZWITTERIONIC POLYMERS WITH THERAPEUTIC MOIETIES | UNIVERSITY OF MASSACHUSETTS (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319569-A1 | ZWITTERIONIC POLYMERS WITH THERAPEUTIC MOIETIES | UNIVERSITY OF MASSACHUSETTS (US) | 2011-12-29 | — | — | US | disclosed |
| EP-2358770-A2 | ZWITTERIONIC POLYMERS WITH THERAPEUTIC MOIETIES | University of Massachusetts (US) | 2011-08-24 | — | — | EP | disclosed |
| WO-2010068862-A2 | ZWITTERIONIC POLYMERS WITH THERAPEUTIC MOIETIES | UNIVERSITY OF MASSACHUSETTS (US) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10632206-B2 | Zwitterionic polymers with therapeutic moieties | PHOSPHO1, PCTP, PAICS | ALDH1A1 2784/4885GAA 3096/4885KDM4E 1529/4885 |
| US-20160346400-A1 | ZWITTERIONIC POLYMERS WITH THERAPEUTIC MOIETIES | PHOSPHO1, PCTP, PAICS | ALDH1A1 2784/4885GAA 3096/4885KDM4E 1529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.