Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 7/20 | 0.52 |
| ▸ | LDHB | P07195 | 5/20 | 0.45 |
| ▸ | KMO | O15229 | 2/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15131309 | 0.86 | LDHA (0.49) | LDHALDHBKMOALDH1A1IKBKB | |
| SCHEMBL902964 | 0.85 | LDHA (0.48) | LDHALDHBKMOALDH1A1IKBKB | |
| SCHEMBL18019282 | 0.85 | SMN1; SMN2 (0.44) | LDHALDHBALDH1A1GAA | |
| SCHEMBL18267291 | 0.78 | ABCG2 (0.44) | LDHALDHBALDH1A1IKBKBCHUK | |
| SCHEMBL30041404 | 0.76 | ACMSD (0.51) | LDHALDHBALDH1A1 | |
| SCHEMBL28859450 | 0.76 | ACMSD (0.51) | LDHALDHBALDH1A1 | |
| SCHEMBL19928398 | 0.74 | LDHA (0.49) | LDHALDHBKMOALDH1A1LMNA | |
| SCHEMBL20256974 | 0.74 | LDHA (0.45) | LDHALDHBKMOALDH1A1 | |
| SCHEMBL15131407 | 0.73 | RXRA (0.44) | LDHALDHBKMOALDH1A1RXRA | |
| SCHEMBL19928394 | 0.73 | LDHA (0.46) | LDHALDHBKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10294225-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | PFIZER INC. (US) | 2019-05-21 | — | — | US | disclosed |
| US-20180162858-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2018-06-14 | — | — | US | disclosed |
| EP-2621493-B1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER (US) | 2016-08-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10294225-B2 | N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors | ACACA, ACACB, PC | LDHA 478/4885LDHB 951/4885KMO 621/4885 |
| US-20180162858-A1 | N1-PYRAZOLOSPIROKETONE ACETYL-CoA CARBOXYLASE INHIBITORS | ACACA, ACACB, PC | LDHA 478/4885LDHB 951/4885KMO 621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.