SCHEMBL18021052

SCHEMBL18021052

Cc1ccc(Oc2ccccc2)cc1OCc1c(C)cccc1-n1nnn(C)c1=O

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 2/20 0.39
PPARG P37231 7/20 0.37
FFAR1 O14842 2/20 0.35
FFAR4 Q5NUL3 1/20 0.35
MGLL Q99685 1/20 0.34
LMNA P02545 1/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
HTT P42858 1/20 0.34
NTRK1 P04629 1/20 0.34
IGF1R P08069 1/20 0.34
FGFR1 P11362 1/20 0.34
NTRK2 Q16620 1/20 0.34
NR1H4 Q96RI1 1/20 0.33
CYP3A4 P08684 1/20 0.32
CYP2C9 P11712 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16442868 0.92 FFAR1 (0.41) PPARGFFAR1FFAR4MGLLLMNA
SCHEMBL18022751 0.91 NTRK1 (0.38) PPARGMGLLLMNANTRK1IGF1R
SCHEMBL16442879 0.90 SLC22A12 (0.36) SLC22A12PPARGFFAR1FFAR4LMNA
SCHEMBL16683840 0.90 LMNA (0.41) SLC22A12PPARGMGLLLMNATSHR
SCHEMBL16442821 0.90 NPC1 (0.40) PPARGLMNAMAPK1NR1H4
SCHEMBL16442829 0.86 PPARG (0.39) SLC22A12PPARGFFAR1FFAR4TSHR
SCHEMBL17806103 0.86 ALDH1A1 (0.39) PPARGFFAR1FFAR4TSHRMAPK1
SCHEMBL17614538 0.86 SLC22A12 (0.41) SLC22A12LMNACYP3A4CYP2C9
SCHEMBL16442830 0.85 PPARG (0.36) PPARGFFAR1FFAR4HTT
SCHEMBL16442831 0.85 NPBWR1 (0.37) PPARGFFAR1FFAR4LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9635857-B2 Tetrazolinone compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-05-02 US disclosed
US-20160235065-A1 TETRAZOLINONE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-08-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160235065-A1 TETRAZOLINONE COMPOUND AND USE THEREOF MRPS17, TAOK1, TAOK3 SLC22A12 3165/4885PPARG 2461/4885FFAR1 2144/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.