Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.39 |
| ▸ | NPC1 | O15118 | 10/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.36 |
| ▸ | HPGD | P15428 | 8/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.35 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 3/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17969409 | 0.84 | PTPN5 (0.39) | RAB9ANPC1KDM4EALDH1A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL17969346 | 0.81 | MET (0.38) | RAB9ANPC1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL17969438 | 0.73 | PTPN5 (0.39) | RAB9ANPC1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL17969349 | 0.71 | ALDH1A1 (0.56) | RAB9ANPC1KDM4EALDH1A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL17969433 | 0.70 | MET (0.37) | RAB9ANPC1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL17969417 | 0.66 | CYP1A2 (0.42) | RAB9ANPC1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL17969344 | 0.66 | PIK3CG (0.46) | RAB9ANPC1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL18595681 | 0.65 | CYP11B2 (0.43) | RAB9ANPC1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL17969403 | 0.64 | ROCK2 (0.40) | RAB9ANPC1KDM4EALDH1A1HSD17B10 | |
| Trifluoroacetic Acid SCHEMBL17969436 | 0.64 | PIK3CA (0.40) | MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016130501-A1 | AZA-HETEROARYL COMPOUNDS AS PI3K-GAMMA INHIBITORS | INCYTE CORPORATION (US) | 2016-08-18 | — | — | WO | disclosed |