Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18034519 | 0.85 | JUN (0.40) | STAT3 | |
| SCHEMBL18034507 | 0.70 | JUN (0.33) | LMNAHTTSMN1; SMN2 | |
| Nagilactone E SCHEMBL30496589 | 0.61 | JUN (0.65) | LMNAPOLBHTTSMN1; SMN2STAT3 | |
| SCHEMBL18034496 | 0.57 | LMNA (0.69) | LMNAPOLBHTTSMN1; SMN2 | |
| SCHEMBL29709891 | 0.56 | JUN (0.52) | STAT3 | |
| SCHEMBL29709940 | 0.54 | JUN (0.78) | STAT3 | |
| SCHEMBL15856565 | 0.52 | MAPT (0.34) | POLBHTT | |
| SCHEMBL18026197 | 0.50 | HIF1A (0.65) | LMNA | |
| SCHEMBL15507620 | 0.49 | PTPN1 (0.34) | LMNA | |
| SCHEMBL15726644 | 0.48 | KDM4E (0.37) | POLBHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016131426-A1 | NAGILACTONE COMPOUNDS HAVING ANTILIPEMIC ACTIVITY, PREPARATION METHOD THEREFOR AND USES THEREOF | 中国科学院上海药物研究所 | 2016-08-25 | — | — | WO | disclosed |