Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.49 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.47 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL527091 | 0.90 | TCF4 (0.52) | ALDH1A1KMT2ACYP17A1PTPN1POLB | |
| SCHEMBL18036557 | 0.88 | HSPD1 (0.53) | AKR1C3ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL527508 | 0.86 | CYP17A1 (0.61) | ALDH1A1MEN1KMT2ACYP17A1HSD17B10 | |
| SCHEMBL527513 | 0.85 | MEN1 (0.62) | ALDH1A1MEN1KMT2AMAPTCYP17A1 | |
| SCHEMBL527060 | 0.85 | CYP17A1 (0.60) | MEN1KMT2ACYP17A1PTPN1PFKFB3 | |
| SCHEMBL526674 | 0.84 | PKM (0.64) | ALDH1A1MEN1KMT2AMAPTCYP17A1 | |
| SCHEMBL526193 | 0.84 | LMNA (0.51) | MEN1KMT2ACYP17A1PTPN1HSPD1 | |
| SCHEMBL526649 | 0.83 | CYP17A1 (0.57) | ALDH1A1MEN1KMT2ACYP17A1POLB | |
| SCHEMBL527006 | 0.82 | GAA (0.63) | ALDH1A1CYP17A1PTPN1 | |
| SCHEMBL527118 | 0.81 | TSHR (0.61) | KMT2AMAPTCYP17A1PTPN1HSPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598481-B1 | SULFONAMIDE COMPOUNDS USEFUL AS CYP17 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2016-08-31 | — | — | EP | claimed |