Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18039665 | 0.82 | DGAT1 (0.42) | CDC7DBF4 | |
| SCHEMBL18039567 | 0.79 | CDC7 (0.52) | ALOX5KDM4EMAPTCYP1A2SMN1; SMN2 | |
| SCHEMBL18039639 | 0.79 | ALOX5 (0.39) | ALOX5PTGESKDM4EMAPTSMN1; SMN2 | |
| SCHEMBL15609313 | 0.78 | RAB9A (0.59) | ALOX5PTGESKDM4EMAPTCYP1A2 | |
| SCHEMBL320206 | 0.77 | PIM1 (0.51) | KDM4EMAPTCYP1A2SMN1; SMN2NPC1 | |
| SCHEMBL16506042 | 0.74 | ALOX5 (0.47) | ALOX5PTGESSMN1; SMN2ALDH1A1TARBP2 | |
| SCHEMBL12209854 | 0.74 | MAP3K14 (0.40) | ALOX5SMN1; SMN2MEN1NPC1RECQL | |
| SCHEMBL5196611 | 0.73 | TRPM8 (0.63) | KDM4EMAPTSMN1; SMN2MEN1NPC1 | |
| SCHEMBL18039307 | 0.73 | GAA (0.41) | KDM4EMAPTCYP1A2SMN1; SMN2MEN1 | |
| SCHEMBL1192529 | 0.73 | CDC7 (0.61) | KDM4EMAPTSMN1; SMN2MEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262035-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2018-01-03 | — | — | EP | disclosed |
| WO-2016135163-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-09-01 | — | — | WO | disclosed |
| WO-2016135163-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-09-01 | — | — | WO | disclosed |