Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18040317 | 1.00 | MAPT (0.37) | MAPTKDM4EGAABLMCYP1B1 | |
| SCHEMBL20709642 | 0.92 | MAPT (0.32) | MAPTKDM4EGAABLMCYP1B1 | |
| SCHEMBL18058766 | 0.87 | AKR1C3 (0.32) | MAPTKDM4EGAABLMCYP1B1 | |
| SCHEMBL1995413 | 0.85 | MAPT (0.50) | MAPTKDM4EGAABLMAKR1C3 | |
| SCHEMBL18058748 | 0.84 | GSK3B (0.39) | — | |
| SCHEMBL20694863 | 0.84 | GSK3B (0.39) | — | |
| SCHEMBL18058838 | 0.83 | MEN1 (0.36) | MAPTKDM4EBLMMEN1KMT2A | |
| SCHEMBL18058759 | 0.82 | S100A4 (0.34) | MAPTBLMMEN1KMT2AALDH1A1 | |
| SCHEMBL15731795 | 0.79 | PIK3R1 (0.39) | MAPTKDM4EGAAMAPK1TDP1 | |
| SCHEMBL20102796 | 0.78 | NR3C2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280714-B1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2019-02-06 | — | — | EP | claimed |
| US-20180118737-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2018-05-03 | — | — | US | claimed |
| EP-3064497-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2016-09-07 | — | — | EP | claimed |
| US-10590133-B2 | Dimer impurities of Apixaban and method to remove them | F.I.S.-FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2020-03-17 | — | — | US | disclosed |
| US-10385049-B2 | Dimer impurities of apixaban and method to remove them | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2019-08-20 | — | — | US | disclosed |
| US-10385049-B2 | Dimer impurities of apixaban and method to remove them | F.I.S.—Fabbrica Italiana Sintetici S.p.A. (IT) | 2019-08-20 | — | — | US | disclosed |
| EP-3280714-B1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2019-02-06 | — | — | EP | disclosed |
| EP-3280714-B1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | FIS FABBRICA ITALIANA SINTETICI SPA (IT) | 2019-02-06 | — | — | EP | disclosed |
| US-20180118737-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2018-05-03 | — | — | US | disclosed |
| US-20180118737-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2018-05-03 | — | — | US | disclosed |
| US-20180118737-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2018-05-03 | — | — | US | disclosed |
| EP-3280714-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S. Fabbrica Italiana Sintetici S.p.A. (IT) | 2018-02-14 | — | — | EP | disclosed |
| WO-2017013079-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2017-01-26 | — | — | WO | disclosed |
| WO-2017013079-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2017-01-26 | — | — | WO | disclosed |
| EP-3064497-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2016-09-07 | — | — | EP | disclosed |
| EP-3064497-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F.I.S.- Fabbrica Italiana Sintetici S.p.A. (IT) | 2016-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10590133-B2 | Dimer impurities of Apixaban and method to remove them | F2, FGB, F8 | MAPT 4678/4885KDM4E 4104/4885GAA 2707/4885 |
| US-10385049-B2 | Dimer impurities of apixaban and method to remove them | F2, FGB, F8 | MAPT 4678/4885KDM4E 4104/4885GAA 2707/4885 |
| US-20180118737-A1 | DIMER IMPURITIES OF APIXABAN AND METHOD TO REMOVE THEM | F2, FGB, F8 | MAPT 4678/4885KDM4E 4104/4885GAA 2707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.