Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1804757 | 0.79 | CES1 (0.60) | L3MBTL1TDP1CES1MAOAMAPK14 | |
| SCHEMBL29437756 | 0.76 | CES1 (0.90) | L3MBTL1TDP1CES1MAOAMAPK14 | |
| SCHEMBL29408351 | 0.76 | CES1 (0.90) | L3MBTL1TDP1CES1MAOAMAPK14 | |
| SCHEMBL44496 | 0.76 | CES1 (0.90) | L3MBTL1TDP1CES1MAOAMAPK14 | |
| SCHEMBL11551043 | 0.74 | ALDH1A1 (0.43) | L3MBTL1TDP1CES1MAOAMAPK14 | |
| SCHEMBL3045257 | 0.73 | CHRM2 (0.67) | TDP1MAPTALDH1A1LMNAMEN1 | |
| SCHEMBL3036634 | 0.73 | CES1 (0.61) | L3MBTL1TDP1CES1MAOAMAPK14 | |
| SCHEMBL7052871 | 0.73 | TDP1 (1.00) | L3MBTL1TDP1CES1MAOAMAPK14 | |
| SCHEMBL1306661 | 0.73 | TDP1 (0.80) | L3MBTL1TDP1CES1MAOAMAPK14 | |
| SCHEMBL13712393 | 0.72 | CES1 (1.00) | L3MBTL1TDP1CES1MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3081213-B1 | TRICYCLIC COMPOUND | KYOWA KIRIN CO LTD (JP) | 2020-04-01 | — | — | EP | disclosed |
| US-9475805-B2 | Tricyclic compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2016-10-25 | — | — | US | disclosed |
| EP-3081213-A1 | TRICYCLIC COMPOUND | Kyowa Hakko Kirin Co., Ltd. (JP) | 2016-10-19 | — | — | EP | disclosed |
| EP-2319840-B1 | AMINOPROPYLIDENE DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2015-12-16 | — | — | EP | disclosed |
| US-20150291587-A1 | TRICYCLIC COMPOUND | KYOWA KIRIN CO., LTD. (JP) | 2015-10-15 | — | — | US | disclosed |
| EP-2243778-B1 | PIPERIDINE DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2014-10-29 | — | — | EP | disclosed |
| US-8653285-B2 | Aminopropylidene derivative | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2014-02-18 | — | — | US | disclosed |
| US-20130267711-A1 | TRICYCLIC COMPOUND | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-10-10 | — | — | US | disclosed |
| US-8486980-B2 | Tricyclic compound | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2013-07-16 | — | — | US | disclosed |
| US-8377967-B2 | Piperidine derivative | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2013-02-19 | — | — | US | disclosed |
| US-20110201640-A1 | TRICYCLIC COMPOUND | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-08-18 | — | — | US | disclosed |
| EP-2327690-A1 | TRICYCLIC COMPOUND | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-06-01 | — | — | EP | disclosed |
| US-20110124856-A1 | AMINOPROPYLIDENE DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2011-05-26 | — | — | US | disclosed |
| EP-2319840-A1 | AMINOPROPYLIDENE DERIVATIVE | Nippon Zoki Pharmaceutical Co., Ltd. (JP) | 2011-05-11 | — | — | EP | disclosed |
| US-20100331365-A1 | PIPERIDINE DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2010-12-30 | — | — | US | disclosed |
| EP-2243778-A1 | PIPERIDINE DERIVATIVE | Nippon Zoki Pharmaceutical Co., Ltd. (JP) | 2010-10-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291587-A1 | TRICYCLIC COMPOUND | PPARA, PPARG, PPARD | L3MBTL1 1512/4885TDP1 4091/4885CES1 228/4885 |
| US-20100331365-A1 | PIPERIDINE DERIVATIVE | HRH4, HRH3, HRH2 | L3MBTL1 4267/4885TDP1 4028/4885CES1 1677/4885 |
| US-20130267711-A1 | TRICYCLIC COMPOUND | PPARA, PPARG, PPARD | L3MBTL1 1512/4885TDP1 4091/4885CES1 228/4885 |
| US-20110124856-A1 | AMINOPROPYLIDENE DERIVATIVE | HRH2, HRH3, HRH4 | L3MBTL1 564/4885TDP1 3965/4885CES1 2989/4885 |
| US-20110201640-A1 | TRICYCLIC COMPOUND | PPARG, PPARA, PPARD | L3MBTL1 1741/4885TDP1 4171/4885CES1 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.