Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 10/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 6/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 5/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.34 |
| ▸ | DRD4 | P21917 | 5/20 | 0.34 |
| ▸ | DRD3 | P35462 | 5/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14641644 | 0.85 | ATAD2 (0.41) | ATAD2CHRM1BRD4GRIN1GRIN2B | |
| SCHEMBL12107604 | 0.77 | ATAD2 (0.39) | ATAD2CHRM1BRD4GRIN1GRIN2B | |
| SCHEMBL12333333 | 0.72 | ATAD2 (0.42) | ATAD2CHRM1CHRM4CHRM5CHRM2 | |
| SCHEMBL12110139 | 0.69 | ESR2 (0.44) | GRIN1GRIN2B | |
| SCHEMBL18421351 | 0.68 | ATAD2 (0.72) | ATAD2CHRM1CHRM4CHRM5CHRM2 | |
| SCHEMBL18055305 | 0.68 | REN (0.42) | RENCYP3A4 | |
| SCHEMBL12110391 | 0.67 | GRIN1 (0.34) | ATAD2CHRM1CHRM4CHRM5CHRM2 | |
| SCHEMBL12110145 | 0.67 | CHRM1 (0.35) | ATAD2CHRM1CHRM4CHRM5CHRM2 | |
| SCHEMBL2061080 | 0.66 | ATAD2 (0.60) | ATAD2CYP1A2CYP11B1CYP11B2SMN1; SMN2 | |
| SCHEMBL2060542 | 0.66 | ATAD2 (0.47) | ATAD2BRD4CYP1A2RENSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2546255-B1 | BENZAZEPINE COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-08-31 | — | — | EP | disclosed |