Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806943 | 0.88 | TDP2 (0.43) | TDP2HTTMAPK10SMN1; SMN2IDO1 | |
| SCHEMBL1806318 | 0.86 | PDE4D (0.50) | TDP2HTTMAPK10SMN1; SMN2IDO1 | |
| SCHEMBL1806748 | 0.79 | PDE4D (0.47) | TDP2HTTMAPK10SMN1; SMN2IDO1 | |
| SCHEMBL1806295 | 0.77 | CA12 (0.35) | SMN1; SMN2NPC1KMT2AMAPTKDM4E | |
| SCHEMBL10921548 | 0.77 | TDP2 (0.42) | TDP2HTTMAPK10SMN1; SMN2IDO1 | |
| SCHEMBL1803979 | 0.76 | TDP2 (0.43) | TDP2SMN1; SMN2KMT2APOLBKDM4E | |
| SCHEMBL1807102 | 0.74 | PDE4D (0.47) | HTTMAPK10SMN1; SMN2NPC1KMT2A | |
| SCHEMBL16682538 | 0.72 | ALPL (0.54) | NPC1KMT2ARAB9APOLBMAPT | |
| SCHEMBL1807745 | 0.72 | PDE4D (0.50) | TDP2HTTMAPK10SMN1; SMN2IDO1 | |
| SCHEMBL1808198 | 0.71 | PDE4D (0.43) | TDP2HTTMAPK10SMN1; SMN2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501703-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060035-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |