Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1809016 | 0.87 | KDM4E (0.48) | KDM4EPOLBKMT2AMEN1NPSR1 | |
| SCHEMBL1803979 | 0.86 | TDP2 (0.43) | KDM4EPOLBKMT2AMEN1NPSR1 | |
| SCHEMBL1806327 | 0.76 | KDM4E (0.44) | KDM4EPOLBSMN1; SMN2CYP1A2ALDH1A1 | |
| SCHEMBL1805096 | 0.75 | PDE4D (0.47) | KDM4EKMT2AMEN1NPSR1SMN1; SMN2 | |
| SCHEMBL1807976 | 0.74 | MAPT (0.43) | KDM4EPOLBNPSR1SMN1; SMN2TP53 | |
| SCHEMBL1806149 | 0.73 | HCAR2 (0.42) | — | |
| SCHEMBL14471201 | 0.73 | SMN1; SMN2 (0.49) | KDM4EPOLBKMT2AMEN1NPSR1 | |
| SCHEMBL23529298 | 0.72 | TSHR (0.56) | KDM4EPOLBKMT2AMEN1NPSR1 | |
| SCHEMBL3810014 | 0.70 | KDM4E (0.58) | KDM4EPOLBKMT2AMEN1NPSR1 | |
| SCHEMBL1806508 | 0.70 | PDE4D (0.49) | KDM4EPOLBKMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501704-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060217-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |