Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806148 | 0.87 | KDM4E (0.46) | KDM4EPOLBKMT2AMEN1NPSR1 | |
| SCHEMBL1803979 | 0.83 | TDP2 (0.43) | KDM4EPOLBKMT2AMEN1JAK2 | |
| SCHEMBL4715742 | 0.77 | KDM4E (0.44) | KDM4EPOLBALOX5KMT2AMEN1 | |
| SCHEMBL1806327 | 0.75 | KDM4E (0.44) | KDM4EPOLBALDH1A1HSD17B10NPC1 | |
| SCHEMBL1807976 | 0.74 | MAPT (0.43) | KDM4EPOLBNPSR1ALDH1A1HSD17B10 | |
| SCHEMBL1807315 | 0.73 | ALDH1A1 (0.38) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL14471201 | 0.72 | SMN1; SMN2 (0.49) | KDM4EPOLBKMT2AMEN1NPSR1 | |
| SCHEMBL25409779 | 0.70 | ALPL (0.57) | ALOX5KMT2ATP53NPC1RAB9A | |
| SCHEMBL15715953 | 0.69 | KDM4E (0.48) | KDM4EPOLBKMT2AMEN1ALDH1A1 | |
| SCHEMBL6852749 | 0.69 | KDM4E (0.57) | KDM4EPOLBKMT2AMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501704-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011060217-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |