Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 11/20 | 0.41 |
| ▸ | CA2 | P00918 | 11/20 | 0.41 |
| ▸ | CA12 | O43570 | 7/20 | 0.41 |
| ▸ | CA9 | Q16790 | 7/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31079916 | 0.78 | MEN1 (0.54) | CA1CA2CA12CA9TDP1 | |
| Bromide SCHEMBL18063126 | 0.76 | BCHE (0.35) | CA1CA2CA12CA9TDP1 | |
| Bromide SCHEMBL18063128 | 0.76 | BCHE (0.35) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL21160682 | 0.71 | CA12 (0.54) | CA1CA2CA12CA9MAOA | |
| SCHEMBL5468068 | 0.71 | TDP1 (0.51) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL3243102 | 0.71 | TDP1 (0.55) | CA1CA2CA12CA9TDP1 | |
| Benzaldehyde SCHEMBL27644828 | 0.71 | IDO1 (0.47) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL9995394 | 0.70 | EPHX2 (0.51) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL17208794 | 0.70 | CA12 (0.65) | CA1CA2CA12CA9TDP1 | |
| SCHEMBL29856376 | 0.70 | CA12 (0.56) | CA1CA2CA12CA9TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9943472-B2 | Acid perspiration resistant fluorescent compounds for treating hair | NOXELL CORPORATION (US) | 2018-04-17 | — | — | US | disclosed |
| US-9913791-B2 | Method for improving acid perspiration resistance of fluorescent compounds on hair | NOXELL CORPORATION (US) | 2018-03-13 | — | — | US | disclosed |
| WO-2016149495-A1 | ACID PERSPIRATION RESISTANT FLUORESCENT COMPOUNDS FOR DYEING HAIR | THE PROCTER & GAMBLE COMPANY (US) | 2016-09-22 | — | — | WO | disclosed |
| US-20160271036-A1 | Method for Improving Acid Perspiration Resistance of Fluorescent Compounds on Hair | WELLA OPERATIONS US, LLC | 2016-09-22 | — | — | US | disclosed |
| WO-2016149490-A1 | METHOD FOR IMPROVING ACID PERSPIRATION RESISTANCE OF FLUORESCENT COMPOUNDS ON HAIR | THE PROCTER & GAMBLE COMPANY (US) | 2016-09-22 | — | — | WO | disclosed |
| US-20160271038-A1 | Acid Perspiration Resistant Fluorescent Compounds for Treating Hair | WELLA OPERATIONS US, LLC | 2016-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160271038-A1 | Acid Perspiration Resistant Fluorescent Compounds for Treating Hair | CUTA, SLC26A4, TRPV1 | CA1 338/4885CA2 410/4885CA12 536/4885 |
| US-20160271036-A1 | Method for Improving Acid Perspiration Resistance of Fluorescent Compounds on Hair | CUTA, POLR1C, NHERF1 | CA1 121/4885CA2 168/4885CA12 280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.