⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL659645 | 1.00 | ALOX5 (0.36) | — | |
| Hydrochloric Acid SCHEMBL3615475 | 0.97 | — | — | |
| SCHEMBL14470274 | 0.88 | NOS3 (0.32) | — | |
| SCHEMBL21130778 | 0.88 | ALOX5 (0.31) | — | |
| SCHEMBL1661228 | 0.88 | ALDH1A1 (0.33) | — | |
| SCHEMBL23696015 | 0.88 | NOS3 (0.32) | — | |
| SCHEMBL10266016 | 0.88 | ALDH1A1 (0.33) | — | |
| SCHEMBL8283396 | 0.88 | ALDH1A1 (0.33) | — | |
| SCHEMBL2076710 | 0.87 | — | — | |
| SCHEMBL895491 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501712-A1 | PROCESS FOR THE SYNTHESIS OF AC-ARG-CYCLO(CYS-D-ALA-HIS-D-PHE-ARG-TRP-CYS)-NH2 | Ipsen Pharma S.a.S. (FR) | 2012-09-26 | — | — | EP | claimed |
| WO-2011060355-A1 | PROCESS FOR THE SYNTHESIS OF AC-ARG-CYCLO(CYS-D-ALA-HIS-D-PHE-ARG-TRP-CYS)-NH2 | IPSEN PHARMA S.A.S (FR) | 2011-05-19 | — | — | WO | claimed |
| US-20090036474-A1 | Quinazoline derivatives for use against cancer | PLE PATRICK | 2009-02-05 | — | — | US | claimed |
| CN-119855815-A | KRAS mutant protein inhibitor, and preparation method and application thereof | 甘李药业股份有限公司 | 2025-04-18 | — | — | CN | disclosed |
| WO-2024141757-A1 | LSD1 MODULATORS | EXSCIENTIA AI LIMITED (GB) | 2024-07-04 | — | — | WO | disclosed |
| WO-2024061333-A1 | KRAS MUTANT PROTEIN INHIBITOR, PREPARATION METHOD THEREFOR, AND USE THEREOF | 甘李药业股份有限公司 | 2024-03-28 | — | — | WO | disclosed |
| EP-4322954-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2023226902-A1 | PREPARATION METHOD FOR KRAS G12C INHIBITOR AND INTERMEDIATE THEREOF | 苏州泽璟生物制药股份有限公司 | 2023-11-30 | — | — | WO | disclosed |
| US-20230339977-A1 | SUBSTITUTED HETEROARYL COMPOUND, AND COMPOSITION AND APPLICATION THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2023-10-26 | — | — | US | disclosed |
| US-20230339977-A1 | SUBSTITUTED HETEROARYL COMPOUND, AND COMPOSITION AND APPLICATION THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2023-10-26 | — | — | US | disclosed |
| CN-116836184-A | Preparation and application of Wee1 kinase inhibitor | 药雅科技(上海)有限公司 | 2023-10-03 | — | — | CN | disclosed |
| US-7157454-B2 | Derivatives of n-(arylsulfonyl)beta-aminoacids comprising a substituted aminomethyl group, the preparation method thereof and the pharmaceutical compositions containing same | SANOFI-AVENTIS (FR) | 2007-01-02 | — | — | US | disclosed |
| WO-2005037860-A2 | INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE | VERTEX PHARMACEUTICALS INCOPORATED (US) | 2005-04-28 | — | — | WO | disclosed |
| EP-0068999-B1 | DERIVATIVES OF 1-ARYL-2-AMINOMETHYL-CYCLOPROPANE-CARBOXAMIDES (Z), THEIR PREPARATION AND THEIR USE AS MEDICINES IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM | PIERRE FABRE S.A. (FR) | 1985-05-22 | — | — | EP | disclosed |
| EP-0068999-A1 | Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (Z), their preparation and their use as medicines in the treatment of disorders of the central nervous system | PIERRE FABRE S.A. (FR) | 1983-01-05 | — | — | EP | disclosed |
| US-4086280-A | FROM M-CHLOROPERBENZOIC ACID AND AN ALKYL ALKENYL TIN COMPOUND TO FORM EPOXIDE, HYDROGEN CHLORIDE | THE PROCTER & GAMBLE COMPANY (US) | 1978-04-25 | — | — | US | disclosed |
| US-4085273-A | REACTING TRIBUTYL(1-CARBOALKOXY-2,2-DIMETHYL-3-BUTEN-1-YL)TIN WITH ACETYL FLUOBORATE, REACTING PRODUCT WITH METHYL METAL COMPOUND, DEHYDRATING PRODUCT WITH IODINE CATALYSIS | THE PROCTER & GAMBLE COMPANY (US) | 1978-04-18 | — | — | US | disclosed |
| US-4065480-A | Process for preparing substituted cyclopropycarbinyl compounds | THE PROCTER & GAMBLE COMPANY (US) | 1977-12-27 | — | — | US | disclosed |
| US-3998889-A | REACTING AN UNSATURATED ORGANO-TIN COMPOUND WITH AN ORGANIC SULFUR HALIDE | THE PROCTER & GAMBLE COMPANY (US) | 1976-12-21 | — | — | US | disclosed |
| US-3959324-A | PESTICIDE, ANTIINFLAMMATORY | THE PROCTER & GAMBLE COMPANY (US) | 1976-05-25 | — | — | US | disclosed |