Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 14/20 | 0.33 |
| ▸ | P2RX2 | Q9UBL9 | 14/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18068091 | 0.88 | KCNK3 (0.35) | P2RX3P2RX2CYP3A4CYP2D6TSHR | |
| SCHEMBL18068018 | 0.77 | P2RX3 (0.47) | P2RX3P2RX2POLBGAAGFER | |
| SCHEMBL21076511 | 0.76 | KCNK3 (0.33) | P2RX3P2RX2 | |
| SCHEMBL18068013 | 0.76 | P2RX3 (0.35) | P2RX3P2RX2CYP3A4CYP2D6TSHR | |
| SCHEMBL18068092 | 0.74 | CYP3A4 (0.32) | CYP3A4CYP2D6TSHRCRHBPCYP2C19 | |
| SCHEMBL18068089 | 0.72 | CYP3A4 (0.36) | CYP3A4CYP2D6TSHRCRHBPCYP2C19 | |
| SCHEMBL12796016 | 0.71 | CA1 (0.33) | — | |
| SCHEMBL12828162 | 0.71 | CYP3A4 (0.33) | P2RX3P2RX2CYP3A4CYP2D6TSHR | |
| SCHEMBL13073948 | 0.71 | PDE2A (0.38) | P2RX3P2RX2CYP3A4CYP2D6TSHR | |
| SCHEMBL20642431 | 0.70 | P2RX3 (0.31) | P2RX3P2RX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10179782-B2 | Substituted sulfonamide compounds | GENENTECH, INC. (US) | 2019-01-15 | — | — | US | disclosed |
| US-20160264567-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | GENENTECH, INC. (US) | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10179782-B2 | Substituted sulfonamide compounds | TRPA1, TRPV1, TRPV5 | P2RX3 32/4885P2RX2 27/4885CYP3A4 816/4885 |
| US-20160264567-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | TRPA1, TRPV1, TRPV5 | P2RX3 32/4885P2RX2 27/4885CYP3A4 816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.