Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 12/20 | 0.34 |
| ▸ | P2RX2 | Q9UBL9 | 12/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18068093 | 0.88 | P2RX3 (0.33) | P2RX3P2RX2CYP3A4CYP2D6TSHR | |
| SCHEMBL21076511 | 0.87 | KCNK3 (0.33) | KCNK3KCNK9P2RX3P2RX2 | |
| SCHEMBL13073948 | 0.83 | PDE2A (0.38) | P2RX3P2RX2CYP3A4CYP2D6TSHR | |
| SCHEMBL12828162 | 0.83 | CYP3A4 (0.33) | KCNK3KCNK9P2RX3P2RX2CYP3A4 | |
| SCHEMBL12828155 | 0.81 | PGK1 (0.39) | P2RX3P2RX2CYP3A4CYP2D6TSHR | |
| SCHEMBL20642400 | 0.79 | P2RX3 (0.35) | KCNK3KCNK9P2RX3P2RX2CYP3A4 | |
| SCHEMBL21076633 | 0.79 | KCNK3 (0.33) | KCNK3KCNK9P2RX3P2RX2 | |
| SCHEMBL21076651 | 0.79 | P2RX3 (0.35) | KCNK3KCNK9P2RX3P2RX2 | |
| SCHEMBL18068018 | 0.78 | P2RX3 (0.47) | P2RX3P2RX2 | |
| SCHEMBL18068013 | 0.77 | P2RX3 (0.35) | P2RX3P2RX2CYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160264567-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | GENENTECH, INC. (US) | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160264567-A1 | SUBSTITUTED SULFONAMIDE COMPOUNDS | TRPA1, TRPV1, TRPV5 | KCNK3 146/4885KCNK9 87/4885P2RX3 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.